Baseline nutritional status could be a predictor for radiation esophagitis in esophageal cancer patients undergoing radiotherapy

被引：21

作者：

Dong, Jie ^{[1
]}

Zhang, Wencheng ^{[2
]}

Zhang, Tian ^{[2
]}

Chen, Xi ^{[2
]}

Zhao, Jingjing ^{[2
]}

Zeng, Yaqi ^{[1
]}

Chen, Yajun ^{[1
]}

Wei, Xiaoying ^{[2
]}

Lei, Tongda ^{[2
]}

Wang, Ping ^{[2
]}

Zhao, Lujun ^{[2
]}

Wang, Jun ^{[2
]}

Yuan, Zhiyong ^{[2
]}

Song, Yongchun ^{[2
]}

Liu, Ningbo ^{[2
]}

Wang, Kun ^{[1
]}

Pang, Qingsong ^{[2
]}

机构：

[1] Tianjin Med Univ Canc Inst & Hosp, Tianjin Tianjins Clin Res Ctr Canc, Dept Nutr Therapy, Natl Clin Res Ctr Canc,Key Lab Canc Prevent & The, Tianjin, Peoples R China

[2] Tianjin Med Univ Canc Inst & Hosp, Tianjin Tianjins Clin Res Ctr Canc, Dept Radiat Oncol, Natl Clin Res Ctr Canc,Key Lab Canc Prevent & The, Tianjin, Peoples R China

来源：

ANNALS OF TRANSLATIONAL MEDICINE | 2020年 / 8卷 / 18期

关键词：

Esophageal cancer; nutrition; Patient-Generated Subjective Global Assessment (PG-SGA); esophagitis; radiotherapy; GLASGOW PROGNOSTIC SCORE; CHEMORADIOTHERAPY; INDICATOR; GPS;

D O I：

10.21037/atm-20-4078

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: To investigate the relationship between baseline nutrition status and radiation esophagitis in patients with esophageal cancer treated by radiation therapy. Methods: A retrospective study was performed on 100 patients with esophageal cancer who was treated with definitive chemoradiotherapy, preoperative chemoradiation and definitive radiotherapy at the Tianjin Medical University Cancer Institute and Hospital from October 2018 and October 2019. We documented the clinical characteristics of patients, including tumor location, clinical stage, treatment, radiation dose, gross tumor volume (GTV), planning tumor volume (PTV) and Atkinsons Dysphagia score (ADS), and we recorded the nutrition status before radiation, including Patient-Generated Subjective Global Assessment (PG-SGA), body mass index (BMI), weight loss percentage in 3 mouths (WL), the level of albumin (ALB), hemoglobin (HB), C-reactive protein (CRP) and Glasgow prognostic score (GPS). These factors were correlated with radiation esophagitis using univariate and multivariate regression analyses. Results: Of 100 patients, 44% patients with PG-SGA score >= 9 at baseline, suggesting severe malnutrition, 41% patients developed grade >= 2 radiation esophagitis. In univariate analysis, dose >40 Gy (P=0.015), PTV >= 495 cm(3) (P=0.049), PG-SGA score >= 9 (P=0.001), WL >= 10% (P=0.019) and ALB level <35 g/L (P=0.043) were significantly associated with grade >= 2 radiation esophagitis. Multivariate analysis revealed that PG-SGA score >= 9 (P=0.042) was the independent predictor of radiation esophagitis. Conclusions: Baseline nutritional status associated with development of grade >= 2 radiation esophagitis in patients with esophageal cancer undergoing radiotherapy.

引用

页数：9

共 26 条

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