Classifier ensemble generation and selection with multiple feature representations for classification applications in computer-aided detection and diagnosis on mammography

This paper presents a novel ensemble classifier framework for improved classification of mammographic lesions in Computer-aided Detection (CADe) and Diagnosis (CADx) systems. Compared to previously developed classification techniques in mammography, the main novelty of proposed method is twofold: (1) the "combined use" of different feature representations (of the same instance) and data resampling to generate more diverse and accurate base classifiers as ensemble members and (2) the incorporation of a novel "ensemble selection" mechanism to further maximize the overall classification performance. In addition, as opposed to conventional ensemble learning, our proposed ensemble framework has the advantage of working well with both weak and strong classifiers, extensively used in mammography CADe and/or CADx systems. Extensive experiments have been performed using benchmark mammogram dataset to test the proposed method on two classification applications: (1) false-positive (FP) reduction using classification between masses and normal tissues, and (2) diagnosis using classification between malignant and benign masses. Results showed promising results that the proposed method (area under the ROC curve (AUC) of 0.932 and 0.878, each obtained for the aforementioned two classification applications, respectively) impressively outperforms (by an order of magnitude) the most commonly used single neural network (AUC = 0.819 and AUC = 0.754) and support vector machine (AUC = 0.849 and AUC = 0.773) based classification approaches. In addition, the feasibility of our method has been successfully demonstrated by comparing other state-of-the-art ensemble classification techniques such as Gentle AdaBoost and Random Forest learning algorithms. (C) 2015 Elsevier Ltd. All rights reserved.