Solid-phase synthesis of phenols and pyridinones via arylboronation/oxidation protocol using aryl bromides

被引：9

作者：

Lee, Younghee ^{[1
]}

Kelly, Martha J. ^{[1
]}

机构：

[1] Locus Pharmaceut Inc, Blue Bell, PA 19422 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 28期

关键词：

solid-phase synthesis; arylboronation; oxidation; phenol; pyridinone;

D O I：

10.1016/j.tetlet.2006.05.034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A sequence of two known reactions, palladium catalyzed arylboronation of arybromide and subsequent oxidation of arylboronate with oxone, has been carried out to prepare functionalized phenols and pyridin-2(1H)-one which were later loaded on to resin for solid-phase synthesis. Using these resin-bound templates, a number of solid-phase methods were developed to generate libraries of substituted phenols and pyridin-2(1H)-one. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4897 / 4901

页数：5

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