Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

被引：943

作者：

Zielinska, Aleksandra ^{[1
,2
]}

Carreiro, Filipa ^{[1
]}

Oliveira, Ana M. ^{[1
]}

Neves, Andreia ^{[1
]}

Pires, Barbara ^{[1
]}

Venkatesh, D. Nagasamy ^{[3
]}

Durazzo, Alessandra ^{[4
]}

Lucarini, Massimo ^{[4
]}

Eder, Piotr ^{[5
]}

Silva, Amelia M. ^{[6
,7
]}

Santini, Antonello ^{[8
]}

Souto, Eliana B. ^{[1
,9
]}

机构：

[1] Univ Coimbra, Fac Pharm, Dept Pharmaceut Technol, Polo Ciencias Saude, P-3000548 Coimbra, Portugal

[2] Polish Acad Sci, Inst Human Genet, Strzeszynska 32, PL-60479 Poznan, Poland

[3] JSS Acad Higher Educ & Res, JSS Coll Pharm, Ooty 643001, Tamil Nadu, India

[4] CREA Res Ctr Food & Nutr, Via Ardeatina 546, I-00178 Rome, Italy

[5] Poznan Univ Med Sci, Dept Gastroenterol Dietet & Internal Dis, Przybyszewskiego 49, PL-60355 Poznan, Poland

[6] Univ Tras Os Montes & Alto Douro, Dept Biol & Environm, UTAD, P-5001801 Vila Real, Portugal

[7] Ctr Res & Technol Agroenvironm & Biol Sci CITAB U, P-5001801 Vila Real, Portugal

[8] Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy

[9] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal

来源：

MOLECULES | 2020年 / 25卷 / 16期

关键词：

polymeric nanoparticles; nanocapsules; nanospheres; therapeutic potential; targeted drug delivery; toxicology; ecotoxicology; IN-VIVO CHARACTERIZATION; DRUG-DELIVERY-SYSTEMS; PLGA NANOPARTICLES; FORMULATION VARIABLES; EX-VIVO; VITRO; NANOCAPSULES; NANOSPHERES; RELEASE; SIZE;

D O I：

10.3390/molecules25163731

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term "nanoparticle" stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.

引用

页数：20

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