Promising use of minocycline augmentation with clozapine in treatment- resistant schizophrenia

被引：12

作者：

Qurashi, I. ^{[1
]}

Collins, J. D. ^{[1
]}

Chaudhry, I. B. ^{[2
,3
]}

Husain, N. ^{[3
]}

机构：

[1] Ashworth Hosp, Maghull L31 1HW, Merseyside, England

[2] Lancashire Care NHS Trust, Preston, Lancs, England

[3] Univ Manchester, Manchester, Lancs, England

来源：

JOURNAL OF PSYCHOPHARMACOLOGY | 2014年 / 28卷 / 07期

关键词：

Minocycline; clozapine; treatment-resistant schizophrenia;

D O I：

10.1177/0269881114527358

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Treatment-resistant schizophrenia is a major health problem in the UK with the majority of patients treated with clozapine. In up to 70% of cases there is only a partial response to clozapine with continuing refractory symptoms. We describe two cases in a UK mental health service where minocycline was found to be useful and well tolerated as an augmentation agent with clozapine in the improvement of previously resistant positive and negative symptoms.

引用

收藏

页码：707 / 708

页数：2

相关论文

共 9 条

[1]

Bartolomeis A, 2012, EUR J PHARMACOL, V5, P1

[2] Minocycline Therapeutic Potential in Psychiatry [J].

Dean, Olivia M. ;

Data-Franco, Joao ;

Giorlando, Francesco ;

Berk, Michael .

CNS DRUGS, 2012, 26 (05) :391-401

[3] Elevated serum levels of C-reactive protein are associated with more severe psychopathology in a subgroup of patients with schizophrenia [J].

Fan, Xiaoduo ;

Pristach, Cynthia ;

Liu, Emily Y. ;

Freudenreich, Oliver ;

Henderson, David C. ;

Goff, Donald C. .

PSYCHIATRY RESEARCH, 2007, 149 (1-3) :267-271

[4] Adjunct minocycline to clozapine treated patients with persistent schizophrenia symptoms [J].

Kelly, Deanna L. ;

Vyas, Gopal ;

Richardson, Charles M. ;

Koola, Maju ;

McMahon, Robert P. ;

Buchanan, Robert W. .

SCHIZOPHRENIA RESEARCH, 2011, 133 (1-3) :257-258

[5] Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia [J].

Levkovitz, Yechiel ;

Levi, Uri ;

Braw, Yoram ;

Cohen, Hagit .

BRAIN RESEARCH, 2007, 1154 :154-162

[6] Minocycline as Adjunctive Therapy for Schizophrenia: An Open-Label Study [J].

Miyaoka, Tsuyoshi ;

Yasukawa, Rei ;

Yasuda, Hideaki ;

Hayashida, Maiko ;

Inagaki, Takuji ;

Horiguchi, Jun .

CLINICAL NEUROPHARMACOLOGY, 2008, 31 (05) :287-292

[7] Clinical Potential of Minocycline for Schizophrenia [J].

Miyaoka, Tsuyoshi .

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2008, 7 (04) :376-381

[8]

Sommer E, 2001, SCHIZOPHR B, V38, P1003

[9] Minocycline attenuates hyperlocomotion and prepulse inhibition deficits in mice after administration of the NMDA receptor antagonist dizocilpine [J].

Zhang, Lin ;

Shirayama, Yukihiko ;

Iyo, Masaomi ;

Hashimoto, Kenji .

NEUROPSYCHOPHARMACOLOGY, 2007, 32 (09) :2004-2010