Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China

被引:13
作者
Cao, Yaying [1 ]
Wang, Tao [2 ]
Wu, Yiqun [1 ]
Juan, Juan [1 ]
Qin, Xueying [1 ]
Tang, Xun [1 ]
Wu, Tao [1 ]
Hu, Yonghua [1 ]
机构
[1] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
[2] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA
基金
中国国家自然科学基金;
关键词
pleiotropic genetic effects; CMIP; type 2 diabetes mellitus; obesity; sex-specific pattern; family-based study; GENOME-WIDE ASSOCIATION; QUANTITATIVE TRAIT LOCI; WAIST-HIP RATIO; GENDER-DIFFERENCES; SUSCEPTIBILITY LOCI; SEXUAL-DIMORPHISM; MELLITUS; VARIANTS; METAANALYSIS; ARCHITECTURE;
D O I
10.3390/ijms19041011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
C-Maf Inducing Protein (CMIP) gene polymorphisms were reported to be associated with type 2 diabetes mellitus (T2DM). Whether the association between CMIP and T2DM is mediated via obesity-related phenotypes is still unclear. We analyzed the association of CMIP rs2925979 with T2DM and a comprehensive set of obesity-related phenotypes in 1576 families ascertained from a Chinese population. These families included a total of 3444 siblings (1582 with T2DM, 963 with prediabetes, and 899 with a normal glucose level). Using multi-level mixed effects regression models, we found that each copy of CMIP rs2925979_T allele was associated with a 29% higher risk of T2DM in females (p = 9.30 x 10(-4)), while it was not significantly associated with T2DM in males (p = 0.705). Meanwhile, rs2925979_T allele was associated with lower levels of body mass index (BMI), waist circumference (WC), hip circumference (HC), percentage of body fat (PBF), PBF of arms, PBF of legs, and PBF of trunk in nondiabetes females (all p < 0.05). The opposite associations of rs2925979_T allele with T2DM and obesity-related phenotypes suggest that CMIP may exert independent pleiotropic effects on T2DM and obesity-related phenotypes in females.
引用
收藏
页数:11
相关论文
共 47 条
[1]   Standards of Medical Care in Diabetes-2014 [J].
不详 .
DIABETES CARE, 2014, 37 :S14-S80
[2]   Genotype-by-sex interaction in the aetiology of type 2 diabetes mellitus: support for sex-specific quantitative trait loci in Hypertension Genetic Epidemiology Network participants [J].
Avery, C. L. ;
Freedman, B. I. ;
Kraja, A. T. ;
Borecki, I. B. ;
Miller, M. B. ;
Pankow, J. S. ;
Arnett, D. ;
Lewis, C. E. ;
Myers, R. H. ;
Hunt, S. C. ;
North, K. E. .
DIABETOLOGIA, 2006, 49 (10) :2329-2336
[3]   Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals [J].
Burgdorf, K. S. ;
Gjesing, A. P. ;
Grarup, N. ;
Justesen, J. M. ;
Sandholt, C. H. ;
Witte, D. R. ;
Jorgensen, T. ;
Madsbad, S. ;
Hansen, T. ;
Pedersen, O. .
DIABETOLOGIA, 2012, 55 (01) :105-113
[4]   Shared genetic influence of BMI, physical activity and type 2 diabetes: a twin study [J].
Carlsson, S. ;
Ahlbom, A. ;
Lichtenstein, P. ;
Andersson, T. .
DIABETOLOGIA, 2013, 56 (05) :1031-1035
[5]   Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins [J].
Cheema, Amanpreet K. ;
Li, Tan ;
Liuzzi, Juan P. ;
Zarini, Gustavo G. ;
Dorak, Mehmet T. ;
Huffman, Fatma G. .
JOURNAL OF DIABETES RESEARCH, 2015, 2015
[6]   Obesity as a Major Risk Factor for Cancer [J].
De Pergola, Giovanni ;
Silvestris, Franco .
JOURNAL OF OBESITY, 2013, 2013
[7]   Measures of general and central obesity and risk of type 2 diabetes in a Ghanaian population [J].
Frank, Laura K. ;
Heraclides, Alexandros ;
Danquah, Ina ;
Bedu-Addo, George ;
Mockenhaupt, Frank P. ;
Schulze, Matthias B. .
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2013, 18 (02) :141-151
[8]   Gender Differences in Insulin Resistance, Body Composition, and Energy Balance [J].
Geer, Eliza B. ;
Shen, Wei .
GENDER MEDICINE, 2009, 6 :60-75
[9]   Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population [J].
Go, Min Jin ;
Hwang, Joo-Yeon ;
Park, Tae-Joon ;
Kim, Young Jin ;
Oh, Ji Hee ;
Kim, Yeon-Jung ;
Han, Bok-Ghee ;
Kim, Bong-Jo .
DIABETES & METABOLISM JOURNAL, 2014, 38 (05) :375-387
[10]   Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization [J].
Grimbert, P ;
Valanciute, A ;
Audard, V ;
Pawlak, A ;
Le gouvelo, S ;
Lang, P ;
Niaudet, P ;
Bensman, A ;
Guellaën, G ;
Sahali, D .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (05) :797-807