Stereoselective synthesis of Neu5Acα(2→5)Neu5Gc:: The building block of oligo/poly(→5-OglycolylNeu5Gcα2→) chains in sea urchin egg cell surface glycoprotein

被引：15

作者：

Fan, GT

Lee, CC

Lin, CC ^{[1
]}

Fang, JM

机构：

[1] Acad Sinica, Inst Chem, Taipei 115, Taiwan

[2] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[3] Natl Changhua Univ Educ, Dept Chem, Changhua 500, Taiwan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 21期

关键词：

D O I：

10.1021/jo025988p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a sialic acid dimer derivative, Neu5Acalpha(2-->5)Neu5Gc, is described. The synthetic strategy is based on the use of allyl alcohol to achieve an exclusive alpha-sialylation product. The allyloxy group is also a latent glycolic acid that provides the subsequent coupling with neuraminate with minimal protection-deprotection manipulations.

引用

收藏

页码：7565 / 7568

页数：4

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