Goodbye Suxamethonium!

被引:53
作者
Lee, C. [1 ]
机构
[1] Harbor UCLA Med Ctr, Dept Anesthesiol, Torrance, CA 90509 USA
关键词
NEUROMUSCULAR BLOCK; SUCCINYLCHOLINE; MUSCLE; ANTAGONISM; ANESTHESIA; MECHANISM;
D O I
10.1111/j.1365-2044.2008.05873.x
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
No drugs in anaesthesia are more problematic than suxamethonium. Yet, no drugs have survived as suxamethonium does in spite of crisis after crisis, and attempt after attempt at its replacement. For decades, suxamethonium has taught us neuromuscular pharmacology and provided us with an encylcopaedia of side effects, while benefiting millions and millions of our anaesthetised patients. With the arrival of sugammadex, it finally appears that suxamethonium can be retired. Suxamethonium has done its job and seen its days! The present review is intended to offer a eulogy for suxamethonium.
引用
收藏
页码:73 / 81
页数:9
相关论文
共 29 条
  • [1] STRUCTURE AND ACTIVITY OF ACETYLCHOLINE
    BEERS, WH
    REICH, E
    [J]. NATURE, 1970, 228 (5275) : 917 - &
  • [2] Critical hemoglobin desaturation will occur before return to an unparalyzed state following 1 mg/kg intravenous succinylcholine
    Benumof, JL
    Dagg, R
    Benumof, R
    [J]. ANESTHESIOLOGY, 1997, 87 (04) : 979 - 982
  • [3] Bis- and mixed-tetrahydroisoquinolinium chlorofumarates: New ultra-short-acting nondepolarizing neuromuscular blockers
    Boros, EE
    Bigham, EC
    Boswell, GE
    Mook, RA
    Patel, SS
    Savarese, JJ
    Ray, JA
    Thompson, JB
    Hashim, MA
    Wisowaty, JC
    Feldman, PL
    Samano, V
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (02) : 206 - 209
  • [5] Bowman W. C., 1980, STRIATED MUSCLE NEUR
  • [6] BOWMAN WC, 1980, ANESTH ANALG, V59, P935
  • [7] DUAL NEUROMUSCULAR BLOCK IN MAN
    CHURCHILLDAVIDSON, HC
    CHRISTIE, TH
    WISE, RP
    [J]. ANESTHESIOLOGY, 1960, 21 (02) : 144 - 149
  • [8] COMPARISON OF INTUBATING CONDITIONS AFTER ADMINISTRATION OF ORG 9426 (ROCURONIUM) AND SUXAMETHONIUM
    COOPER, R
    MIRAKHUR, RK
    CLARKE, RSJ
    BOULES, Z
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 1992, 69 (03) : 269 - 273
  • [9] DONATI F, 1982, ANESTHESIOLOGY, V58, P6
  • [10] NEUROMUSCULAR AND AUTONOMIC BLOCKING ACTIVITIES OF PANCURONIUM, ORG-NC-45, AND OTHER PANCURONIUM ANALOGS, IN THE CAT
    DURANT, NN
    MARSHALL, IG
    SAVAGE, DS
    NELSON, DJ
    SLEIGH, T
    CARLYLE, IC
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1979, 31 (12) : 831 - 836