Mitochondrial activity in T cells

被引：113

作者：

Desdin-Mico, Gabriela ^{[1
,2
]}

Soto-Heredero, Gonzalo ^{[2
]}

Mittelbrunn, Maria ^{[1
,2
]}

机构：

[1] Hosp Univ 12 Octubre I 12, Inst Invest, Ave Cordoba S-N, Madrid 28041, Spain

[2] CSIC UAM, Ctr Biol Mol Severo Ochoa, Nicolas Cabrera 1, Madrid 28049, Spain

来源：

MITOCHONDRION | 2018年 / 41卷

基金：

欧洲研究理事会;

关键词：

Immune synapse; Mitochondrial ROS; Immunometabolism; Organelle communication; Calcium signaling; Inflammation; Immunotherapy; METABOLIC CHECKPOINT; MOLECULAR-MECHANISMS; CA2+ MICRODOMAINS; C-MYC; MEMORY; DIFFERENTIATION; EFFECTOR; BIOGENESIS; ACTIVATION; PLASTICITY;

D O I：

10.1016/j.mito.2017.10.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondria fulfill important and diverse roles during the different stages of T cell adaptive responses. Here we discuss the role of the mitochondria in T cells from the initial steps of activation at the immune synapse to their participation in memory response and T cell exhaustion. Mitochondria are relocated to the immune synapse in order to supply local ATP and to aid calcium signaling. During expansion and proliferation, mitochondrial reactive oxygen species drive proliferation. Aerobic glycolysis, glutaminolysis and fatty acid oxidation regulate the program of differentiation into effector or regulatory T cell subsets, and mitochondrial remodeling proteins are required for the long-lasting phenotype of memory cells.

引用

页码：51 / 57

页数：7

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