Towards precise brain stimulation: Is electric field simulation related to neuromodulation?

被引：99

作者：

Antonenko, Dania ^{[1
,2
,3
,4
,5
]}

Thielscher, Axel ^{[6
,7
]}

Saturnino, Guilherme Bicalho ^{[6
,7
]}

Aydin, Semiha ^{[8
]}

Ittermann, Bernd ^{[8
]}

Grittner, Ulrike ^{[1
,2
,3
,9
,10
]}

Floeel, Agnes ^{[1
,2
,3
,4
,5
,11
]}

机构：

[1] Charite Univ Med Berlin, Charitepl 1, D-10117 Berlin, Germany

[2] Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany

[3] Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany

[4] Berlin Inst Hlth, Dept Neurol, NeuroCure Clin Res Ctr, Charitepl 1, D-10117 Berlin, Germany

[5] Univ Med Greifswald, Dept Neurol, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany

[6] Copenhagen Univ Hosp Hvidovre, Danish Res Ctr Magnet Resonance, Ctr Funct & Diagnost Imaging & Res, Hvidovre, Denmark

[7] Tech Univ Denmark, Dept Elect Engn, Lyngby, Denmark

[8] PTB, Abbestr 2, D-10587 Berlin, Germany

[9] BIH, Anna Louisa Karsch Str 2, D-10178 Berlin, Germany

[10] Berlin Inst Hlth, Inst Biometry & Clin Epidemiol, Charitepl 1, D-10117 Berlin, Germany

[11] German Ctr Neurodegenerat Dis DZNE Standort Greif, Greifswald, Germany

来源：

BRAIN STIMULATION | 2019年 / 12卷 / 05期

关键词：

Transcranial direct current stimulation; Computational modeling; Magnetic resonance spectroscopy; GABA; Resting-state functional magnetic resonance imaging; Brain networks; MOTOR CORTEX STIMULATION; LONG-TERM POTENTIATION; IN-VIVO; GABA; MODULATION; TDCS; SPECTROSCOPY; CONNECTIONS; REVEAL; TOOL;

D O I：

10.1016/j.brs.2019.03.072

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Recent research on neural and behavioral consequences of transcranial direct current stimulation (tDCS) has highlighted the impact of individual factors, such as brain anatomy which determines current field distribution and may thus significantly impact stimulation effects. Computational modeling approaches may significantly advance our understanding of such factors, but the association of simulation-based tDCS-induced fields and neurophysiological outcomes has not been investigated. Objectives: To provide empirical evidence for the relationship between tDCS-induced neurophysiological outcomes and individually induced electric fields. Methods: We applied tDCS during eyes-closed resting-state functional resonance imaging (rsfMRI) and assessed pre-post magnetic resonance spectroscopy (MRS) in 24 participants. We aimed to quantify effects of 15-min tDCS using the "classical" left SM1-right supraorbital area montage on sensorimotor network (SMN) strength and gamma-aminobutyric acid (GABA) and glutamate concentrations, implementing a cross-over counterbalanced design with three stimulation conditions. Additional structural anatomical MRI sequences and recordings of individual electrode configurations allowed individual electric field simulations based on realistic head models of all participants for both conditions. Results: On a neurophysiological level, we observed the expected reduction of GABA concentrations and increase in SMN strength, both during anodal and cathodal compared to sham tDCS, replicating previous results. The magnitudes of neurophysiological modulations induced by tDCS were significantly associated with simulation-based electric field strengths within the targeted left precentral gyms. Conclusion: Our findings corroborate previous reports on tDCS-induced neurophysiological modulations and further advance the understanding of underlying mechanisms by providing first empirical evidence for the association of the injected electric field and neuromodulatory effects. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：1159 / 1168

页数：10

共 64 条

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