Hemophilia and cancer: A new challenge for hemophilia centers

被引：38

作者：

Franchini, Massimo ^{[1
]}

Lippi, Giuseppe ^{[2
]}

Montagnana, Martina ^{[2
]}

Targher, Giovanni ^{[3
]}

Zaffanello, Marco ^{[4
]}

Salvagno, Gian Luca ^{[2
]}

Rivolta, Gianna Franca ^{[5
]}

Di Perna, Caterina ^{[5
]}

Tagliaferri, Annarita ^{[5
]}

机构：

[1] Univ Hosp Parma, Immunohematol & Transfus Ctr, Dept Pathol & Lab Med, Parma, Italy

[2] Univ Verona, Sect Clin Chem, Dept Biomed & Morphol Sci, I-37100 Verona, Italy

[3] Univ Verona, Endocrinol Sect, Dept Biomed & Surg Sci, I-37100 Verona, Italy

[4] Univ Verona, Dept Mother Child & Biol Genet, I-37100 Verona, Italy

[5] Univ Hosp, Reg Reference Ctr Inherited Bleeding Disorders, Parma, Italy

来源：

CANCER TREATMENT REVIEWS | 2009年 / 35卷 / 04期

关键词：

HEPATOCELLULAR-CARCINOMA; COAGULATION DISORDERS; LIFE EXPECTANCY; HEPATITIS-C; MORTALITY; DEATH; LEUKEMIA; POPULATION; THERAPY; PATIENT;

D O I：

10.1016/j.ctrv.2009.01.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The improved life expectancy of hemophilia patients due to the advances in hemophilia care and factor replacement therapy has permitted to hemophiliacs to reach an older age. As a consequence, age-related diseases, Such as cardiovascular disorders and cancer, have been increasingly recognized ill Such patients. In particular, the management of cancer in people with inherited hemorrhagic disorders represents a new challenge for physicians working in hemophilia centers. The few published literature data document that there is a close relationship between hemophilia and neoplasia. Indeed, the congenital bleeding tendency may influence the cancer in different ways, by interfering with its clinical presentation, diagnosis and treatment. These aspects, along with the epidemiology of cancer in hemophiliacs will be discussed in this review. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：374 / 377

页数：4

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