Anti-D in RhD Positive Patient: Auto Anti-D or Anti-LW?

被引：0

作者：

Hassan, Mohd Nazri ^{[1
,2
]}

Zulkafli, Zefarina ^{[1
,2
]}

Wanik, Che Faridah Che ^{[1
,2
]}

Abd Rahman, Wan Suriana Wan ^{[2
,3
]}

Noor, Noor Haslina Mohd ^{[1
,2
]}

Ramli, Marini ^{[1
,2
]}

Iberahim, Salfarina ^{[1
,2
]}

Bahar, Rosnah ^{[1
,2
]}

Yusoff, Shafini Mohamed ^{[1
,2
]}

机构：

[1] Univ Sains Malaysia, Sch Med Sci, Dept Haematol, Kubang Kerian 16150, Kelantan, Malaysia

[2] Univ Sains Malaysia, Hosp USM, Kubang Kerian, Kelantan, Malaysia

[3] Univ Sains Malaysia, Sch Dent Sci, Kubang Kerian, Kelantan, Malaysia

来源：

GAZI MEDICAL JOURNAL | 2021年 / 32卷 / 01期

关键词：

Anti-D; anti-LW; alloantibody; autoantibody;

D O I：

10.12996/gmj.2021.27

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anti-LW and anti-D can be indistinguishable. Therefore, it is important to differentiate them since anti-D is a clinically significant antibody. ICAM4 and RHD genes encode the Landsteiner-Wiener (LW) and RhD antigens, respectively. However, the LW antigens expression requires an interaction with Rh proteins. Hence, LW antigen is being express more strongly by RhD positive (RhD+) than RhD negative (RhD-) individuals. We describe a 51-year-old male with underlying multiple medical problems. His blood group was O RhD+ with Rh phenotype R1r (DCe/dce). The patient had been receiving regular packed cells (PC) transfusion for anemia due to underlying chronic kidney disease. Immunohematology workup showed antibody identification positive for auto-control with anti-D specificity which suggestive for the presence of autoantibody (anti-D or anti-LW). Cross-matching revealed incompatibility with all RhD+ but compatible with RhD-PC. Further investigations should be done to differentiate these two antibodies. The laboratory approaches in order to differentiate anti-LW and anti-D will be discussed and highlighted.

引用

页码：128 / 130

页数：3

共 7 条

[1] The Rh blood group system: a review
Avent, ND
Reid, ME
[J]. BLOOD, 2000, 95 (02) : 375 - 387
[2] Chu Fang-Yeh, IMMUNOHEMATOLOGY CAS
[3] Miola Marcos Paulo, 2013, Rev. Bras. Hematol. Hemoter., V35, P198, DOI 10.5581/1516-8484.20130042
[4] Vaglio Stefania, 2007, Blood Transfus, V5, P44, DOI 10.2450/2007.0008-07
[5] AUTOANTIBODIES IN ACQUIRED HEMOLYTIC-ANEMIA WITH SPECIAL REFERENCE TO LW SYSTEM
VOS, GH
PETZ, LD
GARRATTY, G
FUDENBERG, HH
[J]. BLOOD, 1973, 42 (03) : 445 - 453
[6] The Rh blood group system in review: A new face for the next decade
Westhoff, CM
[J]. TRANSFUSION, 2004, 44 (11) : 1663 - 1673
[7] Westhoff Connie M., 2016, RH LW BLOOD GROUP AN

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