Diagnostic and Prognostic Value of CD10 in Peripheral Nerve Sheath Tumors

被引：0

作者：

Cabibi, Daniela ^{[1
]}

Zerilli, Monica ^{[1
]}

Caradonna, Giuseppe ^{[1
]}

Schillaci, Loredana ^{[1
]}

Belmonte, Beatrice ^{[1
]}

Rodolico, Vito ^{[1
]}

机构：

[1] Univ Palermo, Dept Human Pathol, I-90133 Palermo, Italy

来源：

ANTICANCER RESEARCH | 2009年 / 29卷 / 08期

关键词：

Neurofibroma; malignant peripheral nerve sheath tumors; CD10; neurofibromatosis; STROMAL CELLS; EXPRESSION; CARCINOMA; MARKER;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Neurofibromas are sporadic or associated with type 1 neurofibromatosis (NF1), with a higher risk of malignant progression. Materials and Methods: We investigated CD10 immunoexpression in 39 peripheral nerve sheath lesions. They were 18 typical, solitary, sporadic neurofibromas (group A) and 21 cases (group B) consisting of 11 NF1-associated cases, 3 malignant peripheral sheath tumors (MPNST) and 8 atypical neurofibromas. Results: CD10 immunopositivity was absent or very weak and focal in group A. On the contrary, CD10 was strongly expressed in group B, including all the MPNST and their metastases, with 95% sensitivity and 72% specificity in distinguishing between the two groups. Conclusion: CD10 is useful in the assessment of peripheral sheath tumors and could give evidence that atypical myxoid and/or diffuse neurofibromas, sometimes histologically difficult to distinguish from low-grade MPNST, represent not only a histological but also an immunohistochemical continuum with MPNST.

引用

页码：3149 / 3155

页数：7

共 18 条

[1]

[Anonymous], 1987, Natl Inst Health Consens Dev Conf Consens Statement, V6, P1

[2] CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression [J].