Mesoporous Silica Supraparticles for Sustained Inner-Ear Drug Delivery

被引：61
|
作者：
Wang, Yajun [1 ,2 ]
Wise, Andrew K. [3 ,4 ]
Tan, Justin [4 ]
Maina, James W. [1 ]
Shepherd, Robert K. [3 ,4 ]
Caruso, Frank [1 ]
机构：
[1] Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia
[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[3] Univ Melbourne, Dept Med Bion, Bion Inst, Melbourne, Vic 3002, Australia
[4] Univ Melbourne, Dept Otolaryngol, East Melbourne, Vic 3002, Australia
来源：
SMALL | 2014年 / 10卷 / 21期
基金：
美国国家卫生研究院; 英国医学研究理事会; 中国国家自然科学基金; 澳大利亚研究理事会;
关键词：
POLYMER CAPSULES; DEAFENED COCHLEA; NEUROTROPHINS; NANOPARTICLES; NANOMEDICINE; PARTICLES; ASSEMBLIES; STRATEGIES; SURVIVAL; SURFACE;
D O I：
10.1002/smll.201401767
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mesoporous silica supraparticles (MS-SPs) are prepared via self-assembly of mesoporous silica nanoparticles under capillary force action in confined droplets. The MS-SPs are effective carriers for sustained drug delivery. Animal studies show that these particles are suitable for chronic intracochlear implantation, and neurotrophins released from the MS-SPs can efficiently rescue primary auditory neurons in an in vivo sensorineural hearing loss model. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4244 / 4248
页数：5
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