Mesoporous Silica Supraparticles for Sustained Inner-Ear Drug Delivery

被引：61

作者：

Wang, Yajun ^{[1
,2
]}

Wise, Andrew K. ^{[3
,4
]}

Tan, Justin ^{[4
]}

Maina, James W. ^{[1
]}

Shepherd, Robert K. ^{[3
,4
]}

Caruso, Frank ^{[1
]}

机构：

[1] Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia

[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[3] Univ Melbourne, Dept Med Bion, Bion Inst, Melbourne, Vic 3002, Australia

[4] Univ Melbourne, Dept Otolaryngol, East Melbourne, Vic 3002, Australia

来源：

SMALL | 2014年 / 10卷 / 21期

基金：

美国国家卫生研究院; 英国医学研究理事会; 中国国家自然科学基金; 澳大利亚研究理事会;

关键词：

POLYMER CAPSULES; DEAFENED COCHLEA; NEUROTROPHINS; NANOPARTICLES; NANOMEDICINE; PARTICLES; ASSEMBLIES; STRATEGIES; SURVIVAL; SURFACE;

D O I：

10.1002/smll.201401767

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mesoporous silica supraparticles (MS-SPs) are prepared via self-assembly of mesoporous silica nanoparticles under capillary force action in confined droplets. The MS-SPs are effective carriers for sustained drug delivery. Animal studies show that these particles are suitable for chronic intracochlear implantation, and neurotrophins released from the MS-SPs can efficiently rescue primary auditory neurons in an in vivo sensorineural hearing loss model. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4244 / 4248

页数：5

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