A new approach for the synthesis of bisindoles through AgOTf as catalyst

被引：52

作者：

Beltra, Jorge ^{[1
]}

Concepcion Gimeno, M. ^{[1
]}

Herrera, Raquel P. ^{[2
]}

机构：

[1] Univ Zaragoza, CSIC, ISQCH, Dept Quim Inorgan, E-50009 Zaragoza, Spain

[2] Univ Zaragoza, CSIC, ISQCH, Dept Quim Organ, E-50009 Zaragoza, Spain

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 10卷

关键词：

Ag(I); aldehydes; bisindole; catalysis; indole; NONREARRANGED MONOTERPENOID UNIT; FRIEDEL-CRAFTS ALKYLATION; SIMPLE INDOLE ALKALOIDS; EFFICIENT SYNTHESIS; CANCER CELLS; VIBRIO-PARAHAEMOLYTICUS; CARBONYL-COMPOUNDS; HYDROGEN SULFATE; BOND ACTIVATION; IONIC LIQUIDS;

D O I：

10.3762/bjoc.10.228

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach for the catalyzed formation of bisindolylmethane derivatives (BIMs) is described. This methodology is the unique example where AgOTf has been successfully used for the activation of aldehydes, giving easy access to a broad range of bisindolyl derivatives with excellent results. Moreover, the simplicity and easy operational methodology using a small amount of commercially available AgOTf (1-3 mol %), one of the lowest catalytic charge used in this process to date, makes this procedure an alternative approach for this interesting and appealing reaction.

引用

页码：2206 / 2214

页数：9

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