Stimulation of the rat medullary raphe nuclei induces differential responses in respiratory muscle activity

被引：17

作者：

Besnard, S. ^{[2
]}

Denise, P. ^{[2
]}

Cappelin, B. ^{[3
]}

Dutschmann, M. ^{[1
]}

Gestreau, C. ^{[1
]}

机构：

[1] Univ Aix Marseille 3, CRN2M, CNRS, UMR6231,Dept Physiol Neurovegetat,MP3 Resp, F-13397 Marseille 20, France

[2] Univ Caen, Physiol Lab, UPRES EA 3917, F-14033 Caen 5, France

[3] Univ Poitiers, F-86021 Poitiers, France

来源：

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2009年 / 165卷 / 2-3期

关键词：

Medullary raphe; Serotonin; Stimulation; Sleep; Apnea; PHRENIC-NERVE ACTIVITY; SEROTONERGIC NEURONS; VENTILATORY RESPONSE; SLEEP-APNEA; NEWBORN RAT; RETROTRAPEZOID NUCLEUS; INSPIRATORY ACTIVITY; HYPOGLOSSAL NERVE; RECEPTOR SUBTYPES; PREMOTOR NEURONS;

D O I：

10.1016/j.resp.2008.12.004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Neural control circuits that coordinate the motor activity of the diaphragm (DIA) and the geniohyoid muscle (GH) are potentially involved in pathological conditions such as various forms of sleep apnea. Here we investigated a differential role of the raphe magnus (RMg), pallidus (RPa) and the obscurus (ROb) nuclei in the neural control of DIA and GH muscle activity in rats under volatile anesthesia. In order to characterize a topographical organization of the raphe nuclei we analyzed changes in DIA and GH during high-frequency stimulation (HFS, 10-130 Hz, 60 mu s pulse width, 40-160 mu A 30 s). HFS of the RMg and the ROb induced apnea, in the latter case apnea was associated with massive tonic discharge in the GH. By contrast, HFS of the RPa induced tachypnea. At caudal stimulation sites the tachypnea was accompanied by tonic DIA activity and cessation of GH. These data suggest a differential distribution of inhibitory and excitatory drives of DIA and GH muscles within distinct raphe nuclei. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：208 / 214

页数：7