What can one learn from experiments about the elusive transition state?

被引：25

作者：

Chang, I

Cieplak, M ^{[1
]}

Banavar, JR

Maritan, A

机构：

[1] Polish Acad Sci, Inst Phys, PL-02668 Warsaw, Poland

[2] Penn State Univ, Dept Phys, University Pk, PA 16802 USA

[3] Pusan Natl Univ, Natl Res Lab Computat Prote & Biophys, Dept Phys, Pusan 609735, South Korea

[4] Univ Padua, INFM, I-35131 Padua, Italy

[5] Univ Padua, Dipartimento Fis G Galilei, I-35131 Padua, Italy

[6] Abdus Salam Int Ctr Theoret Phys, I-34100 Trieste, Italy

来源：

PROTEIN SCIENCE | 2004年 / 13卷 / 09期

关键词：

protein folding; transition state; protein engineering;

D O I：

10.1110/ps.04713804

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present the results of an exact analysis of a model energy landscape of a protein to clarify the idea of the transition state and the physical meaning of the phi values determined in protein engineering experiments. We benchmark our findings to various theoretical approaches proposed in the literature for the identification and characterization of the transition state.

引用

页码：2446 / 2457

页数：12

共 53 条

[1] NON-INTERACTING LOCAL-STRUCTURE MODEL OF FOLDING AND UNFOLDING TRANSITION IN GLOBULAR-PROTEINS .2. APPLICATION TO TWO-DIMENSIONAL LATTICE PROTEINS [J].