Anti-HBV and cytotoxic activities of pyranocoumarin derivatives

被引:96
|
作者
Su, Chung-Ren [1 ]
Yeh, Sheau Farn [2 ]
Liu, Chih Miem [2 ]
Damu, Amooru G. [1 ]
Kuo, Tsung-Hsiao [1 ]
Chiang, Po-Cheng [3 ]
Bastow, Kenneth F. [4 ]
Lee, Kuo-Hsiung [3 ]
Wu, Tian-Shung [1 ]
机构
[1] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan
[2] Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan
[3] Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, UNC Eshelman Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA
关键词
Pyranocoumarin derivatives; Anti-HBV; Cytotoxic; CHRONIC HEPATITIS-B; VIRUS; COUMARINS; THERAPY; ROOT;
D O I
10.1016/j.bmc.2008.12.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Four natural pyranocoumarins clausenidin (1), nordentatin (2), clausarin (3), and xanthoxyletin (4) were isolated from the medicinal plant Clausena excavata. Recently, we found that 1 and 2 suppressed hepatitis B virus surface antigen in HepA2 cells, and in addition, 1-3 showed cytotoxic activity against four human cancer cell lines (A549, MCF7, KB, and KB-VIN). To explore the SAR of 1-4, 17 pyranocoumarin analogues (5-21) were designed and synthesized. Among these analogues, 5 and 10 were the most potent against hepatitis B virus with EC50 values of 1.14 and 1.34 mu M, respectively. The most interesting result in the cytotoxicity assay was the significant activity of 1, 5, and 6 against the multi-drug resistant cell line, KB-VIN, without activity against the KB cell line. These data suggest that these three compounds could be useful hits for developing MDR-inverse drugs. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:6137 / 6143
页数:7
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