Synthesis of functionalized carboranes as potential anticancer and BNCT agents

被引：12
作者：
Reddy, Venkata Jaganmohan
Roforth, Matthew M.
Tan, Chalet
Reddy, M. Venkat Ram
机构：
[1] Univ Minnesota, Dept Chem & Biochem, Duluth, MN 55812 USA
[2] Univ Minnesota, Dept Pharm Practice, Duluth, MN 55812 USA
[3] Univ Minnesota, Dept Pharmaceut Sci, Duluth, MN 55812 USA
来源：
INORGANIC CHEMISTRY | 2007年 / 46卷 / 02期
关键词：
D O I：
10.1021/ic061948i
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Carboranyl aldehydes react with alpha,beta-unsaturated esters, ketones, and nitriles in the presence of DABCO to provide functionalized carboranyl alcohols in good yields. Acetates of these alcohols undergo a facile isomerization with a variety of nucleophiles and afford structurally interesting carboranes. Biological evaluation of these molecules exhibited impressive antiproliferative activity for brain and breast cancer cells.
引用
收藏
页码：381 / 383
页数：3
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