Influence of the Structure of the Titanium Oxide Coating Surface on Immunocompetent Tumor Cells

被引：4

作者：

Khlusov, I. A. ^{[1
,2
]}

Sharkeev, Yu. P. ^{[2
,3
]}

Pichugin, V. F. ^{[2
]}

Legostaeva, E. V. ^{[3
]}

Litvinova, L. S. ^{[4
]}

Shupletsova, V. V. ^{[4
]}

Sokhonevich, N. A. ^{[4
]}

Khaziakhmatova, O. G. ^{[4
]}

Khlusova, M. Yu. ^{[1
]}

Gutor, S. S. ^{[1
]}

Tolkacheva, T. V. ^{[3
]}

机构：

[1] Siberian State Med Univ, Tomsk, Russia

[2] Natl Res Tomsk Polytech Univ, Tomsk, Russia

[3] Russian Acad Sci, Inst Strength Phys & Mat Sci, Siberian Branch, Tomsk, Russia

[4] Immanuel Kant Balt Fed Univ, Kaliningrad, Russia

来源：

RUSSIAN PHYSICS JOURNAL | 2016年 / 58卷 / 11期

关键词：

titanium substrates; oxide coatings; roughness; surface potential; titanium nanoparticles; Jurkat; cells; in vitro; APOPTOSIS; ACTIVATION; ADHESION;

D O I：

10.1007/s11182-016-0678-y

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Results of a study of the properties of titanium oxide based coatings deposited on titanium substrates by microarc oxidation are presented that establish a relationship between physical and mechanical properties of the coating surface and their medical and biological properties. The required surface topography is formed by sandblasting of the substrate and is controlled by values of the roughness index Ra. A linear dependence of the amplitude of negative electrostatic potential of the oxide coating on the Ra value is established. The topography of the micro-arc coating surface determines its negative surface potential that apparently reduces the viability of the leukemia D cent cells of the Jurkat line via electrostatic and biological mechanisms unrelated to the generation of intracellular reactive oxygen species.

引用

页码：1527 / 1533

页数：7

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