Molecular targeting in radiotherapy of lung cancer

被引：22
作者：
Baumann, M
Krause, M
Zips, D
Petersen, C
Dittmann, K
Dörr, W
Rodemann, HP
机构：
[1] Tech Univ Dresden, Med Fac Carl Gustav Carus, Dept Radiat Oncol, D-01307 Dresden, Germany
[2] Tech Univ Dresden, Med Fac Carl Gustav Carus, Expt Ctr, D-01307 Dresden, Germany
[3] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, D-01307 Dresden, Germany
[4] Univ Tubingen, Dept Radiat Oncol, Sect Radiobiol & Mol Environm Res, Tubingen, Germany
来源：
LUNG CANCER | 2004年 / 45卷
关键词：
radiotherapy; tumour response; normal tissue reactions; molecular targeting; EGFR; COX-2; angiogenesis; KGF; TGF-beta; BBI; translational research; tumour growth delay; local tumour control;
D O I：
10.1016/j.lungcan.2004.07.975
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Molecular targeting is a promising option to increase the radiation response of tumours and to decrease normal tissue reactions, i.e. to achieve therapeutic gain. Molecular targeting substances in themselves are not curative while radiation is a highly efficient cytotoxic agent, with local recurrences often occurring from only few surviving clonogenic cells. High-dose radiotherapy therefore offers optimal conditions to evaluate the potential of specific biology-driven drugs for oncology. This review summarises the current status of preclinical and clinical research on combined radiation with examples of molecular targeting substances relevant for the treatment of NSCLC (EGFR, COX-2, VEGFR, KGF, TGF-beta, BBI). (C) 2004 Elsevier Science Ltd.
引用
收藏
页码：S187 / S197
页数：11
相关论文
共 120 条
[61]  
KALLMAN RF, 1987, RODENT TUMOR MODELS
[62]  
Kennedy AR, 1996, CANCER RES, V56, P679
[63]   The role of cyclooxygenase-2 in prostate cancer [J].
Kirschenbaum, A ;
Liu, XH ;
Yao, S ;
Levine, AC .
UROLOGY, 2001, 58 (2A) :127-131
[64]  
Kishi K, 2000, CANCER RES, V60, P1326
[65]   Sequential chemo-radiotherapy in non-small cell lung cancer [J].
Kotas, M ;
Willner, J ;
Flentje, M .
LUNG CANCER, 2001, 33 :S61-S64
[66]  
Kozin SV, 2001, CANCER RES, V61, P39
[67]   Adjuvant inhibition of the epidermal growth factor receptor after fractionated irradiation of FaDu human squamous cell carcinoma [J].
Krause, A ;
Hessel, F ;
Zips, D ;
Hilberg, F ;
Baumann, M .
RADIOTHERAPY AND ONCOLOGY, 2004, 72 (01) :95-101
[68]   In regard to Solomon et al.:: EGFR blockade with ZD1839 ("IRESSA") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma.: IJROBP 2003;55:713-723 [J].
Krause, M ;
Baumann, M ;
Thames, HD .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2003, 57 (01) :300-301
[69]  
Krause M, 2003, INT J RADIAT ONCOL, V55, P713
[70]  
Kris M.G., 2002, P AM SOC CLIN ONCOL, V21, p292a
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