Flow-injection chemiluminescence determination of fluoroquinolones

被引:47
作者
Rao, Y
Tong, Y
Zhang, XR [1 ]
Luo, GA
Baeyens, WRG
机构
[1] Tsing Hua Univ, Dept Chem, Beijing 100084, Peoples R China
[2] State Univ Ghent, Fac Pharmaceut Sci, B-9000 Ghent, Belgium
关键词
ofloxacin; norfloxacin; ciprofloxacin; lomefloxacin; chemiluminescence; flow-injection; cerium (IV);
D O I
10.1080/00032710008543113
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A new flow-injection CL method was developed for the determination of fluoroquinolones including ofloxacin, norfloxacin, ciprofloxacin and lomefloxacin in pharmaceutical preparations, based on the chemiluminescence reaction of sulphite with cerium(IV) sensitized by these compounds. The linear ranges are 0.04 to 4.0 mu g ml(-1) for ofloxacin and 0.4 to 40.0 mu g ml(-1) for norfloxacin, ciprofloxacin and lomefloxacin, respectively. The detection limits are 0.016 mu g ml(-1) for ofloxacin and 0.16 mu g ml(-1) for norfloxacin, ciprofloxacin and lomefloxacin, respectively. The relative standard deviations (RSD) are 2.1 to 2.6% (n = 10) for these fluoroquinolones. The analytical procedure has been applied to the determination of the fluoroquinolones in pharmaceutical commercial formulations. The results are in agreement with those obtained by the official methods.
引用
收藏
页码:1117 / 1129
页数:13
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