The heat shock factor HSF1 juggles protein quality control and metabolic regulation

被引：8
|
作者：
Canto, Carles [1 ,2 ]
机构：
[1] Nestle Inst Hlth Sci, CH-1015 Lausanne, Switzerland
[2] Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
来源：
JOURNAL OF CELL BIOLOGY | 2017年 / 216卷 / 03期
关键词：
STRESS-RESPONSE; THERMOTOLERANCE; DISEASE; SIRT1; AMPK;
D O I：
10.1083/jcb.201701093
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Transcriptional regulators often act as central hubs to integrate multiple nutrient and stress signals. In this issue, Qiao et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607091) demonstrate how heat shock factor 1 (HSF1) uncouples metabolic control from proteostatic regulation and unveils HSF1 as a critical transcriptional regulator of NAD+ metabolism. © 2017 Cantó.
引用
收藏
页码：551 / 553
页数：3
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