Total synthesis of tubulysin U and V

被引：98

作者：

Doemling, Alexander

Beck, Barbara

Eichelberger, Uwe

Sakamuri, Sukumar

Menon, Sanjay

Chen, Quin-Zene

Lu, Yingchun

Wessjohann, Ludger A.

机构：

[1] R& Biopharmaceutu GmbH, D-82152 Martinsried, Germany

[2] Leibniz Inst Pflanzenbiochem, Abt Nat & Wirkstoffchem, D-06120 Halle, Germany

[3] Morphochem Inc, Monmouth Jct, NJ 08852 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 43期

关键词：

antitumor agents; multicomponent reactions; natural products; peptide coupling; thiazoles;

D O I：

10.1002/anie.200601259

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multicomponent method: Tubulysins are among the most potent cytotoxic agents known. Now the first total synthesis of some members has been achieved by utilizing a rapid three-component reaction for the synthesis of the unusual central thiazole amino acid tubuvaline (see scheme; Boc = tert-butoxycarbonyl, Ac = acetyl), thereby opening new perspectives for anticancer drug development. (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：7235 / 7239

页数：5

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