Antioxidants in fruits and vegetables: a study of cellular availability and direct effects on human DNA

被引:13
作者
Szeto, Yim Tong [1 ]
Chu, Wing Kwan [1 ]
Benzie, Iris F. F. [1 ]
机构
[1] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Kowloon, Hong Kong, Peoples R China
关键词
antioxidant; ascorbic acid; comet assay; fruit; lysed cell;
D O I
10.1271/bbb.60224
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effects of several types of whole fruits and vegetables on human lymphocytic DNA were investigated by using two versions of the comet assay. The total antioxidative capacity, as the FRAP value, and ascorbic acid (AA) content were also measured to explore the relationship between the effect and antioxidant content.
引用
收藏
页码:2551 / 2555
页数:5
相关论文
共 32 条
[1]   DNA damage from micronutrient deficiencies is likely to be a major cause of cancer [J].
Ames, BN .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2001, 475 (1-2) :7-20
[2]  
Benzie IFF, 1999, METHOD ENZYMOL, V299, P15
[3]   Evolution of dietary antioxidants [J].
Benzie, IFF .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2003, 136 (01) :113-126
[4]   Mechanisms of antioxidant and pro-oxidant effects of α-lipoic acid in the diabetic and nondiabetic kidney [J].
Bhatti, F ;
Mankhey, RW ;
Asico, L ;
Quinn, MT ;
Welch, WJ ;
Maric, C .
KIDNEY INTERNATIONAL, 2005, 67 (04) :1371-1380
[5]   MICRONUTRIENTS AND CANCER - TIME FOR ACTION [J].
BLOCK, G .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (11) :846-848
[6]  
Collins A, 1997, ENVIRON MOL MUTAGEN, V30, P139, DOI 10.1002/(SICI)1098-2280(1997)30:2<139::AID-EM6>3.0.CO
[7]  
2-I
[8]   Determination of flavonoids in citrus juices by micro-HPLC-ESI/MS [J].
Dugo, P ;
Lo Presti, M ;
Öhman, M ;
Fazio, A ;
Dugo, G ;
Mondello, L .
JOURNAL OF SEPARATION SCIENCE, 2005, 28 (11) :1149-1156
[9]   Antioxidants prevent the lymphocyte DNA damage induced by PMA-stimulated monocytes [J].
Fabiani, R ;
De Bartolomeo, A ;
Rosignoli, P ;
Morozzi, G .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2001, 39 (02) :284-291
[10]   Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo [J].
Graziani, G ;
D'Argenio, G ;
Tuccillo, C ;
Loguercio, C ;
Ritieni, A ;
Morisco, F ;
Blanco, CD ;
Fogliano, V ;
Romano, M .
GUT, 2005, 54 (02) :193-200