Association of polymorphisms in CTLA-4, IL-1ra and IL-1β genes with multiple sclerosis in Serbian population

被引：30

作者：

Dincic, Evica

Zivkovic, Maja

Stankovic, Aleksandra

Obradovic, Dragana

Alavantic, Dragan

Kostic, Vladimir

Raicevic, Ranko

机构：

[1] Vinca Inst Nucl Sci, Lab Radiobiol & Mol Genet, Belgrade 11001, Serbia

[2] Mil Med Acad, Dept Neurol, Belgrade 11001, Serbia

[3] Clin Ctr Serbia, Inst Neurol, Belgrade, Serbia

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2006年 / 177卷 / 1-2期

关键词：

IL-1; beta; IL-1ra; CTLA-4; gene; polymorphisms; multiple sclerosis;

D O I：

10.1016/j.jneuroim.2006.05.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have investigated separate as well as combined influence of IL-1 beta TaqI, IL-1ra VNTR and CTLA-4 +49 A/G polymorphisms on susceptibility, clinical course and progression of MS in 162 Serbian patients. We found significant independent relative risk for MS susceptibility in noncarriers of IL-Ira allele 2 (OR=2.2, CI= 1.3-3.7, p=0.003) and CTLA-4 +49 AA genotype (OR=2.0, CI=1.2-3.5, p=0.01) as well as their combined effect (OR=4.4, CI=2.0-9.7, p=0.0003). Our result supports the significant and combined effect of IL-1ra VNTR and CTLA-4 polymorphisms on MS justifying the need for further haplotype analysis in different populations. (c) 2006 Elsevier B.V. All rights reserved.

引用

收藏

页码：146 / 150

页数：5

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