Modulatory effect of 8-OH-DPAT on behavior of ovariectomized female rats

被引：0
作者：
Sapronov, NS [1 ]
Fedotova, YO [1 ]
Malygina, EI [1 ]
机构：
[1] Russian Acad Med Sci, Inst Expt Med, SV Anichkov Dept Neuropharmacol, St Petersburg P 22, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2004年 / 137卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
8-OH-DPAT; passive avoidance; plus-maze; behavior; estrogens; pharmacotherapy;
D O I：
10.1023/B:BEBM.0000024383.75037.d1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Behavior of ovariectomized rats was studied after chronic administration of serotonin 1A receptor agonist 8-OH-DPAT alone or in combination with 17beta-estradiol for 14 days. The effect of 8-OH-DPAT on learning was evaluated in the conditioned passive avoidance task. Behavioral activity in elevated plus-maze and open field was recorded. Administration of 8-OH-DPAT to ovariectomized female rats increased the number of entries into open arms of the maze and the time spent there. Combination treatment of ovariectomized animals with 8-OH-DPAT and 17beta-estradiol decreased total locomotor and emotional activity in the open field. Administration of 8-OH-DPAT alone or in combination with 17beta-estradiol improved performance of the conditioned passive avoidance response.
引用
收藏
页码：43 / 46
页数：4
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