Liquid extraction surface analysis field asymmetric waveform ion mobility spectrometry mass spectrometry for the analysis of dried blood spots

被引：49

作者：

Griffiths, Rian L. ^{[1
]}

Dexter, Alex ^{[1
]}

Creese, Andrew J. ^{[1
]}

Cooper, Helen J. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

来源：

ANALYST | 2015年 / 14卷 / 20期

基金：

英国工程与自然科学研究理事会;

关键词：

TOP-DOWN; INTACT PROTEINS; METABOLISM; PROTEOMICS; SAMPLES; PLATFORM; TISSUE; LIPIDS; TOOL; MS;

D O I：

10.1039/c5an00933b

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Liquid extraction surface analysis (LESA) is a surface sampling technique that allows electrospray mass spectrometry analysis of a wide range of analytes directly from biological substrates. Here, we present LESA mass spectrometry coupled with high field asymmetric waveform ion mobility spectrometry (FAIMS) for the analysis of dried blood spots on filter paper. Incorporation of FAIMS in the workflow enables gas-phase separation of lipid and protein molecular classes, enabling analysis of both haemoglobin and a range of lipids (phosphatidylcholine or phosphatidylethanolamine, and sphingomyelin species) from a single extraction sample. The work has implications for multiplexed clinical assays of multiple analytes.

引用

页码：6879 / 6885

页数：7

共 40 条

[1] Separation of leucine and isoleucine by electrospray ionization-high field asymmetric waveform ion mobility spectrometry-mass spectrometry [J].

Barnett, DA ;

Ells, B ;

Guevremont, R ;

Purves, RW .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1999, 10 (12) :1279-1284

[2] Application of ESI-FAIMS-MS to the analysis of tryptic peptides [J].

Barnett, DA ;

Ells, B ;

Guevremont, R ;

Purves, RW .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2002, 13 (11) :1282-1291

[3] Miniaturized Ultra High Field Asymmetric Waveform Ion Mobility Spectrometry Combined with Mass Spectrometry for Peptide Analysis [J].

Brown, L. J. ;

Toutoungi, D. E. ;

Devenport, N. A. ;

Reynolds, J. C. ;

Kaur-Atwal, G. ;

Boyle, P. ;

Creaser, C. S. .

ANALYTICAL CHEMISTRY, 2010, 82 (23) :9827-9834

[4] Automated surface sampling of lipids from worn contact lenses coupled with tandem mass spectrometry [J].

Brown, Simon H. J. ;

Huxtable, Liam H. ;

Willcox, Mark D. P. ;

Blanksby, Stephen J. ;

Mitchell, Todd W. .

ANALYST, 2013, 138 (05) :1316-1320

[5] A cross-platform toolkit for mass spectrometry and proteomics [J].

Chambers, Matthew C. ;

Maclean, Brendan ;

Burke, Robert ;

Amodei, Dario ;

Ruderman, Daniel L. ;

Neumann, Steffen ;

Gatto, Laurent ;

Fischer, Bernd ;

Pratt, Brian ;

Egertson, Jarrett ;

Hoff, Katherine ;

Kessner, Darren ;

Tasman, Natalie ;

Shulman, Nicholas ;

Frewen, Barbara ;

Baker, Tahmina A. ;

Brusniak, Mi-Youn ;

Paulse, Christopher ;

Creasy, David ;

Flashner, Lisa ;

Kani, Kian ;

Moulding, Chris ;

Seymour, Sean L. ;

Nuwaysir, Lydia M. ;

Lefebvre, Brent ;

Kuhlmann, Frank ;

Roark, Joe ;

Rainer, Paape ;

Detlev, Suckau ;

Hemenway, Tina ;

Huhmer, Andreas ;

Langridge, James ;

Connolly, Brian ;

Chadick, Trey ;

Holly, Krisztina ;

Eckels, Josh ;

Deutsch, Eric W. ;

Moritz, Robert L. ;

Katz, Jonathan E. ;

Agus, David B. ;

MacCoss, Michael ;

Tabb, David L. ;

Mallick, Parag .

NATURE BIOTECHNOLOGY, 2012, 30 (10) :918-920

[6]

Crawford E, 2011, BIOANALYSIS, V3, P1217, DOI [10.4155/bio.11.99, 10.4155/BIO.11.99]

[7] Use of the dried blood spot sampling process coupled with fast gas chromatography and negative-ion chemical ionization tandem mass spectrometry: application to fluoxetine, norfluoxetine, reboxetine, and paroxetine analysis [J].

Deglon, Julien ;

Lauer, Estelle ;

Thomas, Aurelien ;

Mangin, Patrice ;

Staub, Christian .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 396 (07) :2523-2532

[8] Metabonomics of Newborn Screening Dried Blood Spot Samples: A Novel Approach in the Screening and Diagnostics of Inborn Errors of Metabolism [J].

Denes, Julia ;

Szabo, Eszter ;

Robinette, Steven L. ;

Szatmari, Ildiko ;

Szonyi, Laszlo ;

Kreuder, Joachim G. ;

Rauterberg, Ernst W. ;

Takats, Zoltan .

ANALYTICAL CHEMISTRY, 2012, 84 (22) :10113-10120

[9] Compound heterozygotes and beta-thalassemia: Top-down mass spectrometry for detection of hemoglobinopathies [J].

Edwards, Rebecca L. ;

Griffiths, Paul ;

Bunch, Josephine ;

Cooper, Helen J. .

PROTEOMICS, 2014, 14 (10) :1232-1238

[10] Top-Down Proteomics and Direct Surface Sampling of Neonatal Dried Blood Spots: Diagnosis of Unknown Hemoglobin Variants [J].

Edwards, Rebecca L. ;

Griffiths, Paul ;

Bunch, Josephine ;

Cooper, Helen J. .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2012, 23 (11) :1921-1930

← 1 2 3 4 →