p53 and MDM2 expression in odontogenic cysts and tumours

被引：0
|
作者：
Carvalhais, JN
de Aguiar, MCF
de Araújo, VC
de Araújo, NS
Gomez, RS
机构：
[1] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, BR-30380030 Belo Horizonte, MG, Brazil
[2] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, Sao Paulo, Brazil
来源：
ORAL DISEASES | 1999年 / 5卷 / 03期
关键词：
p53; MDM2; odontogenic cysts; odontogenic tumours; immunohistochemistry;
D O I：
暂无
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
OBJECTIVE: The aim of this report was to assess p53 and MDM2 expression in odontogenic cysts and tumours, as they are known to play important roles in cell proliferation and tumorigenesis. MATERIALS AND METHODS: The expression of p53 and MDM2 proteins was determined immunohistochemically in 51 formalin-fixed, paraffin embedded specimens of odontogenic cysts and tumours. RESULTS: No positivity to p53 was found in the cases studied. MDM2 expression in ameloblastoma was higher than in radicular cysts, but lower than that observed in odontogenic keratocysts. No difference was observed between MDM2 expression in radicular cyst and adenomatoid odontogenic tumour. The clear-cell odontogenic ametoblastoma presented strong immunoreaction to this antigen. CONCLUSIONS: The results suggest that MDM2 overexpression may be involved in the pathogenesis of some odontogenic lesions.
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页码：218 / 222
页数：5
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