Synthesis and Anticancer Activity of 1,2,3-Triazole Fused N-Arylpyrazole Derivatives

被引：19

作者：

Lakkakula, R. ^{[1
]}

Roy, A. ^{[1
]}

Mukkanti, K. ^{[2
]}

Sridhar, G. ^{[3
]}

机构：

[1] GVK Biosci Private Ltd, Med Chem Div, IDA Mallapur, 28A Nacharam, Hyderabad 500076, Telangana, India

[2] Jawaharlal Nehru Technol Univ Hyderabad, Dept Chem, Hyderabad 500085, Telangana, India

[3] CSIR Indian Inst Chem Technol, Organ & Biomol Chem Div, Hyderabad 50010, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 04期

关键词：

celecoxib; rimonabant; pyrazole; 1,2,3-triazole and anticancer activity; 1.3-DIPOLARE CYCLOADDITIONEN; BIOLOGICAL EVALUATION; PYRAZOLE DERIVATIVES; ORGANISCHER AZIDE;

D O I：

10.1134/S1070363219040315

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel series of triazole derivatives 11a-11j is synthesized. Structures of the products are confirmed by H-1 and C-13 NMR, and mass spectral data. The anticancer activities of compounds 11a-11j are evaluated against three human cancer cell lines (MCF-7, A549, and A375) using the standard MTT assay in vitro, using doxorubicin as the positive control. All the compounds exhibit significant activity against cancer cell lines. The compounds 11a, 11d, 11e, 11g, and 11j demonstrate more potent activity than the positive control.

引用

页码：831 / 835

页数：5

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