Bioavailability of polyphenols from peanut skin extract associated with plasma lipid lowering function

被引：38

作者：

Bansode, Rishipal R. ^{[1
]}

Randolph, Priscilla ^{[1
]}

Ahmedna, Mohamed ^{[2
]}

Hurley, Steven ^{[3
]}

Hanner, Tracy ^{[3
]}

Baxter, Sarah A. Schwatrz ^{[4
]}

Johnston, Thomas A. ^{[4
]}

Su, Mingming ^{[4
]}

Holmes, Bryce M. ^{[5
]}

Yu, Jianmei ^{[5
]}

Williams, Leonard L. ^{[1
]}

机构：

[1] North Carolina Agr & Tech State Univ, Ctr Excellence Postharvest Technol, Kannapolis, NC 28081 USA

[2] Qatar Univ, Dept Hlth Sci, Doha, Qatar

[3] North Carolina Agr & Tech State Univ, Dept Anim Sci, Greensboro, NC 27411 USA

[4] David H Murdoch Res Inst, Kannapolis, NC 28081 USA

[5] North Carolina Agr & Tech State Univ, Dept Family & Consumer Sci, Greensboro, NC 27411 USA

来源：

FOOD CHEMISTRY | 2014年 / 148卷

关键词：

Procyanidins; Peanut skin; Polyphenols; Flavanoids; Hypolipidemia; PROCYANIDIN DIMERS; RATS; OBESITY; ACCUMULATION; ABSORPTION; CHILDREN; AMPK; B2;

D O I：

10.1016/j.foodchem.2013.09.129

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Peanut skin is a rich source of polyphenols including procyanidins and is shown to have hypolipidemic properties. This study investigated the bioavailability of peanut skin polyphenols using a rat model. First, the bioavailability of peanut skin polyphenols in rat plasma was evaluated. Our results showed procyanidin A2 levels in plasma peaked within 30 min of ingestion. The results of a second study show that peanut skin extract supplemented in addition to oil gavage resulted in significant decrease in plasma triglyceride and VLDL within 5 h. In the third study, rats were given a Western type diet for 5 weeks with peanut skin extract at a dose of 150 and 300 mg/kg body weight. The main effects observed were lowering of total blood lipid and reduction of the plasma fatty acids profile. Our results suggest that procyanidin A may impart a key role of hypolipidemic effect seen in peanut skin polyphenols. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：24 / 29

页数：6

共 30 条

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