The synthesis of benzoxaboroles and their applications in medicinal chemistry

被引：47

作者：

Zhang Jiong ^{[1
]}

Zhu MingYan ^{[1
]}

Lin YiNan ^{[1
]}

Zhou HuChen ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

来源：

SCIENCE CHINA-CHEMISTRY | 2013年 / 56卷 / 10期

关键词：

benzoxaboroles; synthetic methods; medicinal chemistry; ARYLBORONIC ACIDS; ANTIFUNGAL AGENT; POTENTIAL TREATMENT; COUPLING REACTION; ARYL HALIDES; DISCOVERY; AN2690; DRUGS; CYCLOTRIMERIZATION; DIALKOXYBORANE;

D O I：

10.1007/s11426-013-4981-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Benzoxaborole, as a versatile scaffold, plays important roles in organic synthesis, molecular recognition and supramolecular chemistry. It is also a privileged structure in medicinal chemistry due to its desirable physicochemical and drug-like properties. Recently, benzoxaboroles were widely applied as antifungal, antibacterial, antiviral, anti-parasite, and anti-inflammatory agents. This review covers the properties, synthetic methods and applications of benzoxaboroles in medicinal chemistry.

引用

页码：1372 / 1381

页数：10

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