Polyketides with New Delhi Metallo-β-lactamase 1 Inhibitory Activity from Penicillium sp.

被引：37
作者：
Gan, Maoluo [1 ,2 ,3 ]
Liu, Yufeng [2 ,3 ,4 ]
Bai, Yinlei [1 ,2 ]
Guan, Yan [1 ,2 ]
Li, Li [2 ,3 ]
Gao, Rongmei [1 ,2 ]
He, Weiying [1 ,2 ]
You, Xuefu [1 ,2 ]
Li, Yuhuan [1 ,2 ]
Yu, Liyan [1 ,2 ]
Xiao, Chunling [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
[3] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[4] Jining Med Coll, Jining 272067, Shandong, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 09期
基金：
北京市自然科学基金;
关键词：
BIOSYNTHESIS; METABOLITES; POLIVIONE; ENTEROBACTERIACEAE; STREPTOTHRICINS; CITROMYCETIN; THEOBROXIDE; DERIVATIVES; FREQUENTANS; PRODUCTS;
D O I：
10.1021/np4000944
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new polyketide compounds (1-3), a new quinolone alkaloid (4), and seven known polyketide derivatives were identified from the cultures of Penicillium sp. I09F 484, a strain isolated from the rhizosphere soil of the plant Picea asperata from Kanas Lake, Xinjiang, China. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of 1 and 4 were established by quantum chemical time-dependent density functional theory electronic circular dichroism calculation and Marfey's method, respectively. Compounds 1 and 2 displayed inhibitory activity against New Delhi metallo-beta-lactamase 1 with IC50 values of 94.9 and 87.9 mu M, respectively.
引用
收藏
页码：1535 / 1540
页数：6
相关论文
共 47 条
  • [1] Screening for metabolites from Penicillium novae-zeelandiae displaying radical-scavenging activity and oxidative mutagenicity:: isolation of gentisyl alcohol
    Alfaro, C
    Urios, A
    González, MC
    Moya, P
    Blanco, M
    [J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2003, 539 (1-2) : 187 - 194
  • [2] [Anonymous], 2005, INT C HARM ICH TECHN
  • [3] [Anonymous], 2003, GAUSSIAN 03, Revision C.03
  • [4] ARAI K, 1989, CHEM PHARM BULL, V37, P3229
  • [5] Metallo-β-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily
    Bebrone, Carine
    [J]. BIOCHEMICAL PHARMACOLOGY, 2007, 74 (12) : 1686 - 1701
  • [6] CRYSTAL AND MOLECULAR-STRUCTURE OF COMPACTIN, A NEW ANTIFUNGAL METABOLITE FROM PENICILLIUM-BREVICOMPACTUM
    BROWN, AG
    SMALE, TC
    KING, TJ
    HASENKAMP, R
    THOMPSON, RH
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (11): : 1165 - 1173
  • [7] Chemical Computing Group, 2009, MOL OP ENV MOE 2009
  • [8] Flavonoid Glucuronides and a Chromone from the Aquatic Macrophyte Stratiotes aloides
    Conrad, Juergen
    Foerster-Fromme, Bemhard
    Constantin, Mihaela-Anca
    Ondrus, Vladimir
    Mika, Sabine
    Mert-Balci, Fadime
    Klaiber, Iris
    Pfannstiel, Jens
    Moeller, Wolfgang
    Roesner, Harald
    Foerster-Fromme, Karin
    Beifuss, Uwe
    [J]. JOURNAL OF NATURAL PRODUCTS, 2009, 72 (05): : 835 - 840
  • [9] Cox RJ, 2010, COMPREHENSIVE NATURAL PRODUCTS II: CHEMISTRY AND BIOLOGY, VOL 1: NATURAL PRODUCTS STRUCTURAL DIVERSITY-I: SECONDARY METABOLITES: ORGANIZATION AND BIOSYNTHESIS, P347
  • [10] The current state of ab initio calculations of optical rotation and electronic circular dichroism spectra
    Crawford, T. Daniel
    Tam, Mary C.
    Abrams, Micah L.
    [J]. JOURNAL OF PHYSICAL CHEMISTRY A, 2007, 111 (48) : 12057 - 12068
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