Polyketides with New Delhi Metallo-β-lactamase 1 Inhibitory Activity from Penicillium sp.

被引:37
作者
Gan, Maoluo [1 ,2 ,3 ]
Liu, Yufeng [2 ,3 ,4 ]
Bai, Yinlei [1 ,2 ]
Guan, Yan [1 ,2 ]
Li, Li [2 ,3 ]
Gao, Rongmei [1 ,2 ]
He, Weiying [1 ,2 ]
You, Xuefu [1 ,2 ]
Li, Yuhuan [1 ,2 ]
Yu, Liyan [1 ,2 ]
Xiao, Chunling [1 ,2 ]
机构
[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
[3] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[4] Jining Med Coll, Jining 272067, Shandong, Peoples R China
来源
JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 09期
基金
北京市自然科学基金;
关键词
BIOSYNTHESIS; METABOLITES; POLIVIONE; ENTEROBACTERIACEAE; STREPTOTHRICINS; CITROMYCETIN; THEOBROXIDE; DERIVATIVES; FREQUENTANS; PRODUCTS;
D O I
10.1021/np4000944
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Three new polyketide compounds (1-3), a new quinolone alkaloid (4), and seven known polyketide derivatives were identified from the cultures of Penicillium sp. I09F 484, a strain isolated from the rhizosphere soil of the plant Picea asperata from Kanas Lake, Xinjiang, China. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of 1 and 4 were established by quantum chemical time-dependent density functional theory electronic circular dichroism calculation and Marfey's method, respectively. Compounds 1 and 2 displayed inhibitory activity against New Delhi metallo-beta-lactamase 1 with IC50 values of 94.9 and 87.9 mu M, respectively.
引用
收藏
页码:1535 / 1540
页数:6
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