Biocompatibility of Modified Bionanocellulose and Porous Poly(ε-caprolactone) Biomaterials

被引：9

作者：

Grobelski, Bartlomiej ^{[1
]}

Wach, Radoslaw A. ^{[2
,3
]}

Adamus, Agnieszka ^{[3
]}

Olejnik, Alicja K. ^{[3
]}

Kowalska-Ludwicka, Karolina ^{[2
]}

Kolodziejczyk, Marek ^{[2
]}

Bielecki, Stanislaw ^{[2
]}

Rosiak, Janusz M. ^{[3
]}

Pasieka, Zbigniew ^{[4
]}

机构：

[1] Lodz Univ Technol, Fac Pharm, PL-90924 Lodz, Poland

[2] Lodz Univ Technol, Inst Tech Biochem, PL-90924 Lodz, Poland

[3] Lodz Univ Technol, Inst Appl Radiat Chem, PL-90924 Lodz, Poland

[4] Med Univ Lodz, Dept Expt Surg, Lodz, Poland

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2014年 / 63卷 / 10期

关键词：

cytotoxicity; in vivo biocompatibility; bionanocellulose; tissue response; poly(epsilon-caprolactone); BACTERIAL CELLULOSE; MICROBIAL CELLULOSE; REGENERATION; TISSUE;

D O I：

10.1080/00914037.2013.854223

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Biocompatibility of modified bionanocellulose (BC) and porous poly(epsilon caprolactone) (PCL) were compared to UHMWPE. For all the materials lack of cytotoxic effect to mouse fibroblasts was observed in vitro. In vivo study, subcutaneous implantations in Wistar rats, lasted for seven, 14, and 30 days. Subsequently the composition of surrounding tissue and explants surface changes was evaluated. No symptoms of acute inflammation were observed. Surrounding tissue thickness, the number of granulocytes, lymphocytes, macrophages, and blood vessels differed in time and revealed regular healing process. It is concluded that investigated PCL and BC are the materials with superior biocompatibility with high application potential.

引用

页码：518 / 526

页数：9

共 20 条

[1]

Bielecki S, 2011, A method of production of a cartilage-like biomaterial designed for reconstructive surgery-Eine Methode zur Produktion von Knorpel-ahnlichem Material fur die rekonstruktive Chirurgie-La methode de la formation de biomateriel avec la snecificite de car, Patent No. [EP2371401A2, 2371401, EP2371401 (A2)]

[2]

Bielecki S, 2013, PERSPECT NANOTECHNOL, P157

[3] Polycaprolactone microparticles and their biodegradation [J].

Chen, DR ;

Bei, JZ ;

Wang, SG .

POLYMER DEGRADATION AND STABILITY, 2000, 67 (03) :455-459

[4]

Chu C. C., 1981, J APPL POLYM SCI, V26, P1734

[5] Engineering cartilage tissue [J].

Chung, Cindy ;

Burdick, Jason. A. .

ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (02) :243-262

[6] Microbial cellulose - the natural power to heal wounds [J].

Czaja, W ;

Krystynowicz, A ;

Bielecki, S ;

Brown, RM .

BIOMATERIALS, 2006, 27 (02) :145-151

[7] Poly (ε-caprolactone) biomaterial sterilized by E-beam irradiation [J].

Filipczak, K ;

Wozniak, M ;

Ulanski, P ;

Olah, L ;

Przybytniak, G ;

Olkowski, RM ;

Lewandowska-Szumiel, M ;

Rosiak, JM .

MACROMOLECULAR BIOSCIENCE, 2006, 6 (04) :261-273

[8]

Galas E., 1997, Polish Patent, Patent No. [PL 171,952, 171952]

[9] A literature review of poly(lactic acid) [J].

Garlotta, D .

JOURNAL OF POLYMERS AND THE ENVIRONMENT, 2001, 9 (02) :63-84

[10]

Grobelski B, 2009, LANGENBECK ARCH SURG, V394, P1144

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