Clinical, histopathological and immunohistochemical findings in a case of megakaryoblastic leukemia in a dog

被引：9

作者：

Park, HM

Doster, AR

Tashbaeva, RE

Lee, YM

Lyoo, YS

Lee, SJ

Kim, HJ

Sur, JH ^{[1
]}

机构：

[1] Konkuk Univ, Coll Vet Med, Dept Vet Pathol, Small Anim Tumor Diagnost Ctr, Seoul 143701, South Korea

[2] Konkuk Univ, Coll Vet Med, Dept Vet Internal Med, Seoul 143701, South Korea

[3] Univ Nebraska, Dept Vet & Biomed Sci, Lincoln, NE 68583 USA

来源：

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION | 2006年 / 18卷 / 03期

关键词：

anemia; dog; immunohistochemistry; megakaryoblastic leukemia; M7; pathology;

D O I：

10.1177/104063870601800311

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The clinical, hematological, and histopathologic features of megakaryoblastic leukemia (M7) were investigated in a 10-year-old female Shih-Tzu dog. Megakaryoblastic leukemia was diagnosed using antihuman platelet glycoprotein (GP IIIa) and anti-human von Willebrand factor (vWF) antibodies. The expression of CD antigen on megakaryoblasts was also assessed using a CD79a monoclonal antibody. Immunological markers allowed visualization of neoplastic megakaryocytes. Antibodies against platelet GP IIIa were demonstrated to be the most useful for the diagnosis of megakaryoblastic leukemia of paraffin-embedded canine tissues. Hematological and histological data coupled with immunohistochemical reactivity for platelet GP IIIa, vWF, and CD79a antigen in blast cells confirmed a diagnosis of M7 megakaryoblastic leukemia.

引用

页码：287 / 291

页数：5

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