Protective Effect of Kaempferol on the Transgenic Drosophila Model of Alzheimer's Disease

被引：110

作者：

Beg, Tanveer ^{[1
]}

Jyoti, Smita ^{[2
]}

Naz, Falaq ^{[2
]}

Rahul ^{[2
]}

Ali, Fahad ^{[2
]}

Ali, Syed Kashif ^{[3
]}

Reyad, Ahmed Mohamed ^{[1
]}

Siddique, Yasir Hasan ^{[2
]}

机构：

[1] Jazan Univ, Fac Sci, Biol Dept, Jazan, Saudi Arabia

[2] Aligarh Muslim Univ, Fac Life Sci, Dept Zool, Drosophila Transgen Lab,Sect Genet, Aligarh 202002, Uttar Pradesh, India

[3] Jazan Univ, Fac Sci, Chem Dept, Jazan, Saudi Arabia

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2018年 / 17卷 / 06期

关键词：

Kaempferol; Alzheimer's disease; Drosophila; PARKINSONS-DISEASE; ACETYLCHOLINESTERASE INHIBITION; DIETARY SUPPLEMENTATION; ANTIOXIDANT ACTIVITY; MEDICINAL-PLANTS; POTENTIAL-MODEL; IN-VITRO; FLAVONOIDS; CELLS; ACID;

D O I：

10.2174/1871527317666180508123050

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Alzheimer's disease (AD) is characterized by the accumulation and deposition of beta-amyloid peptides leading to a progressive neuronal damage and cell loss. Besides several hypotheses for explaining the neurodegenerative mechanisms, oxidative stress has been considered to be one of them. Till date, there is no cure for AD, but the pathogenesis of the disease could be delayed by the use of natural antioxidants. In this context, we decided to study the effect of kaempferol against the transgenic Drosophila expressing human amyloid beta-42. Method: The AD flies were allowed to feed on the diet having 10, 20, 30 and 40 mu M of kaempferol for 30 days. After 30 days of exposure, the amyloid beta flies were studied for their climbing ability and Aversive Phototaxis Suppression assay. Amyloid beta flies head homogenate was prepared for estimating the oxidative stress markers, Caspase and acetylcholinesterase activity. Results: The results of the present study reveal that the exposure of AD flies to kaempferol delayed the loss of climbing ability, memory, reduced the oxidative stress and acetylcholinesterase activity. Conclusion: Kaempferol could be used as a possible therapeutic agent against the progression of the Alzheimer's disease.

引用

页码：421 / 429

页数：9