Serotonin Transporter Gene (SLC6A4) Methylation Associates With NeonatalIntensive Care Unit Stay and 3-Month-Old Temperament in Preterm Infants

被引：68

作者：

Montirosso, Rosario ^{[1
]}

Provenzi, Livio ^{[1
]}

Fumagalli, Monica ^{[2
]}

Sirgiovanni, Ida ^{[2
]}

Giorda, Roberto ^{[1
]}

Pozzoli, Uberto ^{[1
]}

Beri, Silvana ^{[1
]}

Menozzi, Giorgia ^{[1
]}

Tronick, Ed ^{[3
,4
]}

Morandi, Francesco ^{[5
]}

Mosca, Fabio ^{[2
]}

Borgatti, Renato ^{[1
]}

机构：

[1] IRCCS Eugenio Medea, Bosisio Parini, Italy

[2] Univ Milan, I-20122 Milan, Italy

[3] Univ Massachusetts, Amherst, MA 01003 USA

[4] Div Newborn Med, New York, NY USA

[5] Sacra Famiglia Hosp, Erba, Italy

来源：

CHILD DEVELOPMENT | 2016年 / 87卷 / 01期

关键词：

NEONATAL INTENSIVE-CARE; EPIGENETIC MECHANISMS; DOPAMINE-D4; RECEPTOR; DEVELOPMENTAL CARE; BRAIN-DEVELOPMENT; STRESS REGULATION; 1ST YEAR; PROMOTER; CHILDREN; BEHAVIOR;

D O I：

10.1111/cdev.12492

中图分类号：

G44 [教育心理学];

学科分类号：

0402 ; 040202 ;

摘要：

Preterm birth and Neonatal Intensive Care Unit (NICU) stay are early adverse stressful experiences, which may result in an altered temperamental profile. The serotonin transporter gene (SLC6A4), which has been linked to infant temperament, is susceptible to epigenetic regulation associated with early stressful experience. This study examined a moderation model in which the exposure to NICU-related stress and SLC6A4 methylation moderated infant temperament at 3months of age. SLC6A4 methylation at 20 CpG sites was quantified in preterm infants (N=48) and full-term infants (N=30) from Italian middle-class families. Results suggested that in preterm infants NICU-related stress might be associated with alterations of serotonergic tone as a consequence of SLC6A4 methylation, which in turn, might associate with temperamental difficulties assessed at 3months of age.

引用

页码：38 / 48

页数：11