Nigerloxin, a novel inhibitor of aldose reductase and lipoxygenase with free radical scavenging activity from Aspergillus niger CFR-W-105

被引：22

作者：

Rao, KCS ^{[1
]}

Divakar, S ^{[1
]}

Babu, KN ^{[1
]}

Rao, AGA ^{[1
]}

Karanth, NG ^{[1
]}

Sattur, AP ^{[1
]}

机构：

[1] Cent Food Technol Res Inst, Fermentat Technol & Bioengn Dept, Mysore 570013, Karnataka, India

来源：

JOURNAL OF ANTIBIOTICS | 2002年 / 55卷 / 09期

关键词：

D O I：

10.7164/antibiotics.55.789

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An enzyme inhibitor, nigerloxin, with inhibition against soy bean lipoxygenase-I (LOX-1), rat lens aldose reductase (RLAR) as well as free radical scavenging activity was isolated from the fermented wheat bran using Aspergillus niger CFR-W-105. Its chemical structure was identified as 2-amido-3-hydroxy-6-methoxy-5-methyl-4-(prop-l'-enyl) benzoic acid by NMR and GCEIMS data. The IC50 values against LOX-1 and RLAR were found to be 79 mum and 69 mum and ED50 against 1,1-diphenyl-2-picrylhydrazyl (DPPH) was 66 mum.

引用

页码：789 / 793

页数：5

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