Small dose pre-irradiation induced radioresistance and longevity after challenging irradiation in splenectomized C57BL/6 mice

被引：0

作者：

Horie, K ^{[1
]}

Kubo, K ^{[1
]}

Kondo, H ^{[1
]}

Yonezawa, M ^{[1
]}

机构：

[1] Univ Osaka Prefecture, Grad Sch Agr & Biol Sci, Div Vet Sci, Dept Vet Radiol, Sakai, Osaka 5998531, Japan

来源：

RADIATION AND HOMEOSTASIS, PROCEEDINGS | 2002年 / 1236卷

关键词：

radioadaptive response; life span; small dose effects; longevity; survival rate;

D O I：

10.1016/S0531-5131(01)00863-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pre-irradiation with 0.45 Gy of X-rays significantly decreased bone marrow death rate after challenging high-dose exposure to 6.75 Gy in splenectomized mice. However, tile increment of the 30-day survival rate was smaller compared with that of the intact animals. The life span after day 30 of the control and pre-irradiated groups of mice was observed. The median survival time was 121 days for the control and 182 days for the pre-irradiated group. Statistical analyses by generalized Wilcoxon's rank sum test and log rank test showed that the pre-irradiation significantly elongated the life span of the high-dose irradiated mice. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：467 / 469

页数：3