Detection of Delta F508 mutation in cystic fibrosis patients from Northwestern Mexico

In order to know the frequency of Delta F508 allele in Northwestern Mexican patients with cystic fibrosis, we carried out the amplification of a region from exon 10 of the CF gene by means of PCR in 45 unrelated patients selected by sweat test and clinical criteria, From 90 chromosomes, only 31 (34.4 %) showed the Delta F508 mutation, distributed in 9 homozygotes and 13 heterozygotes, These result suggest that other mutations are responsible of CF in the population of Northwestern Mexico.