Representation of internal models of action in the autistic brain

被引：221

作者：

Haswell, Courtney C. ^{[1
]}

Izawa, Jun ^{[1
]}

Dowell, Lauren R. ^{[2
]}

Mostofsky, Stewart H. ^{[2
,3
,4
]}

Shadmehr, Reza ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Kennedy Krieger Inst, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 08期

关键词：

DIFFERENT ARM ORIENTATIONS; SIMILAR HAND PATHS; MOTOR CORTEX; SPECTRUM DISORDERS; REACHING MOVEMENTS; INDIVIDUAL CELLS; IMITATION; DYSPRAXIA; CHILDREN; DORSAL;

D O I：

10.1038/nn.2356

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation.

引用

页码：970 / 972

页数：3

共 15 条

[1] Dyspraxia in autism: association with motor, social, and communicative deficits [J].

Dziuk, M. A. ;

Larson, J. C. Gidley ;

Apostu, A. ;

Mahone, E. M. ;

Denckla, M. B. ;

Mostofsky, S. H. .

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2007, 49 (10) :734-739

[2] Localization of white matter volume increase in autism and developmental language disorder [J].

Herbert, MR ;

Ziegler, DA ;

Makris, N ;

Filipek, PA ;

Kemper, TL ;

Normandin, JJ ;

Sanders, HA ;

Kennedy, DN ;

Caviness, VS .

ANNALS OF NEUROLOGY, 2004, 55 (04) :530-540

[3] Internal models of limb dynamics and the encoding of limb state [J].

Hwang, Eun Jung ;

Shadmehr, Reza .

JOURNAL OF NEURAL ENGINEERING, 2005, 2 (03) :S266-S278

[4] Motor signs distinguish children with high functioning autism and Asperger's syndrome from controls [J].

Jansiewicz, Eva M. ;

Goldberg, Melissa C. ;

Newschaffer, Craig J. ;

Denckla, Martha B. ;

Landa, Rebecca ;

Mostofsky, Stewart H. .

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2006, 36 (05) :613-621

[5] Neuronal correlates of motor performance and motor learning in the primary motor cortex of monkeys adapting to an external force field [J].

Li, CSR ;

Padoa-Schioppa, C ;

Bizzi, E .

NEURON, 2001, 30 (02) :593-607

[6] Motor learning by observing [J].

Mattar, AAG ;

Gribble, PL .

NEURON, 2005, 46 (01) :153-160

[7] Increased motor cortex white matter volume predicts motor impairment in autism [J].

Mostofsky, Stewart H. ;

Burgess, Melanie R. ;

Larson, Jennifer C. Gidley .

BRAIN, 2007, 130 :2117-2122

[8] Developmental dyspraxia is not limited to imitation in children with autism spectrum disorders [J].

Mostofsky, Stewart H. ;

Dubey, Prachi ;

Jerath, Vandna K. ;

Jansiewicz, Eva M. ;

Goldberg, Melissa C. ;

Denckla, Martha B. .

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2006, 12 (03) :314-326

[9] Mirror neurons and imitation: A computationally guided review [J].

Oztop, Erhan ;

Kawato, Mitsuo ;

Arbib, Michael .

NEURAL NETWORKS, 2006, 19 (03) :254-271

[10] Imitation and pantomime in high-functioning adolescents with autism spectrum disorders [J].

Rogers, SJ ;

Bennetto, L ;

McEvoy, R ;

Pennington, BF .

CHILD DEVELOPMENT, 1996, 67 (05) :2060-2073

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