Representation of internal models of action in the autistic brain

被引：215

作者：

Haswell, Courtney C. ^{[1
]}

Izawa, Jun ^{[1
]}

Dowell, Lauren R. ^{[2
]}

Mostofsky, Stewart H. ^{[2
,3
,4
]}

Shadmehr, Reza ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Kennedy Krieger Inst, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 08期

关键词：

DIFFERENT ARM ORIENTATIONS; SIMILAR HAND PATHS; MOTOR CORTEX; SPECTRUM DISORDERS; REACHING MOVEMENTS; INDIVIDUAL CELLS; IMITATION; DYSPRAXIA; CHILDREN; DORSAL;

D O I：

10.1038/nn.2356

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation.

引用

页码：970 / 972

页数：3

共 15 条

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