Progress toward a peptidomimetic of laminin-derived pentapeptide YIGSR:: Synthesis of the unique tricyclic core structure

被引：5

作者：

Busqué, F ^{[1
]}

Hopkins, SA ^{[1
]}

Konopelski, JP ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 17期

关键词：

D O I：

10.1021/jo025847n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The peptide sequence YIGSR, a segment of the basement membrane matrix glycoprotein laminin, has been identified as a key component in tumor cell invasion. Guided by extensive NMR work and de novo design algorithms, a nonpeptide mimetic of this pentapeptide was identified as a lead candidate for synthesis. The target displays the key amino acid side chains from a novel tricyclic scaffold. The first synthesis of this unique scaffold is completed in 11 steps and 7% overall yield.

引用

页码：6097 / 6103

页数：7