IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity

被引：115

作者：

Sosa, Lucas

Dupraz, Sebastian

Laurino, Lisandro

Bollati, Flavia

Bisbal, Mariano

Caceres, Alfredo

Pfenninger, Karl H.

Quiroga, Santiago ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Quim Biol, RA-5000 Cordoba, Argentina

[2] Consejo Nacl Invest Cient & Tecn, CIQUIBIC, Cordoba, Argentina

[3] Consejo Nacl Invest Cient & Tecn, INIMEC, Cordoba, Argentina

[4] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA

[5] Univ Colorado, Ctr Canc, Aurora, CO 80045 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 08期

关键词：

D O I：

10.1038/nn1742

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors.

引用

页码：993 / 995

页数：3

共 15 条

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