A facile synthesis of ferrocene grafted N-methyl-spiropyrrolidines through 1,3-dipolar cycloaddition of azomethine ylides

被引：30

作者：

Sureshbabu, A. R. ^{[1
]}

Raghunathan, R. ^{[1
]}

Satiskumar, B. K. ^{[2
]}

机构：

[1] Univ Madras, Dept Chem, Madras 600025, Tamil Nadu, India

[2] Presidency Coll, Dept Phys, Madras 600005, Tamil Nadu, India

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 23期

关键词：

Ferrocene; Cycloaddition; Azomethine ylide; Spiroheterocycles; Spiropyrrolidines; ONE-POT SYNTHESIS; MEDIATED 3+2 CYCLOADDITION; ANTIMALARIAL ACTIVITY; IN-VITRO; DERIVATIVES;

D O I：

10.1016/j.tetlet.2009.03.175

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot synthesis of novel ferrocene grafted N-methyl-spiropyrrolidines has been accomplished in good yields through a facile 1,3-dipolar cycloaddition reaction of various azomethine ylide derived from ninhydrin and sarcosine with various ferrocene derivatives as dipolarophile. The regiochemical and stereochemical outcome of the cycloaddition reaction is ascertained by X-ray crystallographic studies of one of the cycloadducts. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2818 / 2821

页数：4

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