The diverse functions of MicroRNAs in animal development and disease

被引：1961

作者：

Kloosterman, Wigard P.

Plasterk, Ronald H. A.

机构：

[1] Hubrecht Lab, Ctr Biomed Genet, NL-3584 CT Utrecht, Netherlands

[2] Univ Utrecht, NL-3508 TC Utrecht, Netherlands

来源：

DEVELOPMENTAL CELL | 2006年 / 11卷 / 04期

关键词：

D O I：

10.1016/j.devcel.2006.09.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in detail. miRNAs have been implicated in tissue morphogenesis, cellular processes like apoptosis, and major signaling pathways. Emerging evidence suggests a direct link between miRNAs and disease, and miRNA expression signatures are associated with various types of cancer. In addition, the gain and loss of miRNA target sites appears to be causal to some genetic disorders. Here, we discuss the current literature on the role of miRNAs in animal development and disease.

引用

收藏

页码：441 / 450

页数：10

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