V2O5/ZrO2 as an efficient reusable catalyst for the facile, green, one-pot synthesis of novel functionalized 1,4-dihydropyridine derivatives

被引：47

作者：

Bhaskaruni, Sandeep V. H. S. ^{[1
]}

Maddila, Suresh ^{[1
]}

van Zyl, Werner E. ^{[1
]}

Jonnalagadda, Sreekantha B. ^{[1
]}

机构：

[1] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Chiltern Hills, ZA-4000 Durban, South Africa

来源：

CATALYSIS TODAY | 2018年 / 309卷

基金：

新加坡国家研究基金会;

关键词：

Green synthesis; One-pot multicomponent reactions; Heterogeneous catalysis; Reusability; Zirconia; Pyridines; MULTICOMPONENT SYNTHESIS; HANTZSCH REACTION; SULFATED ZIRCONIA; AQUEOUS-MEDIA; C-C; DIHYDROPYRIDINES; DECHLORINATION; OXIDE;

D O I：

10.1016/j.cattod.2017.05.038

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A practical method is designated for the one-pot, multicomponent synthesis of 1,4-dihydropyridine derivatives by cyclo-condensation of aromatic aldehydes, 5,5-dimethyl-1,3-cyclohexanedione, acetoacetanilide and ammonium acetate. Using ethanol as solvent and V2O5/ZrO2 as heterogeneous catalyst, ten novel 1,4-dihydropyridines were synthesized at room temperature (Reaction time< 20 min). XRD, TEM, SEM and BET analysis were used to characterize the catalyst materials. Simple work-up, green solvent, short reaction times, moderate reaction conditions and excellent yields (90-96%) are the attractive features of this novel approach. With no need of chromatographic separation, the reaction product is easily separable in pure form.

引用

页码：276 / 281

页数：6

共 66 条

[1] Poly(vinylpyrrolidinium) perchlorate as a new and efficient catalyst for the promotion of the synthesis of polyhydroquinoline derivatives via Hantzsch condensation [J].