UPA and uPAR in fibrinolysis, immunity and pathology

被引：258
作者：
Mondino, A
Blasi, F
机构：
[1] San Raffaele Sci Inst, DIBIT, Dept Mol Biol & Funct Genom, I-20132 Milan, Italy
[2] San Raffaele Sci Inst, Dept Immunol & Infect Dis, Canc Immunotherapy & Gene Therapy Prog, DIBIT, I-20132 Milan, Italy
来源：
TRENDS IN IMMUNOLOGY | 2004年 / 25卷 / 08期
关键词：
D O I：
10.1016/j.it.2004.06.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The urokinase plasminogen activator (uPA) and its receptor (uPAR) exert pleiotropic functions over the course of both physiological and pathological processes. Data generated in deficient mice have underlined how uPA not only has a key role in fibrinolysis but also modulates the development of protective immunity. By contrast, uPAR anchors uPA at the cell surface and, in addition to favoring extracellular matrix degradation, regulates cell migration, cell adhesion and cell proliferation, thus influencing the development of inflammatory and immune responses. Here, we review the expression and function of uPA and uPAR, and correlate their role in fibrinolysis with immune, infectious and proliferative disorders. This Review is the second in a series on interactions between haemostasis and inflammation.
引用
收藏
页码：450 / 455
页数：6
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