UPA and uPAR in fibrinolysis, immunity and pathology

被引：259
作者：
Mondino, A
Blasi, F
机构：
[1] San Raffaele Sci Inst, DIBIT, Dept Mol Biol & Funct Genom, I-20132 Milan, Italy
[2] San Raffaele Sci Inst, Dept Immunol & Infect Dis, Canc Immunotherapy & Gene Therapy Prog, DIBIT, I-20132 Milan, Italy
来源：
TRENDS IN IMMUNOLOGY | 2004年 / 25卷 / 08期
关键词：
D O I：
10.1016/j.it.2004.06.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The urokinase plasminogen activator (uPA) and its receptor (uPAR) exert pleiotropic functions over the course of both physiological and pathological processes. Data generated in deficient mice have underlined how uPA not only has a key role in fibrinolysis but also modulates the development of protective immunity. By contrast, uPAR anchors uPA at the cell surface and, in addition to favoring extracellular matrix degradation, regulates cell migration, cell adhesion and cell proliferation, thus influencing the development of inflammatory and immune responses. Here, we review the expression and function of uPA and uPAR, and correlate their role in fibrinolysis with immune, infectious and proliferative disorders. This Review is the second in a series on interactions between haemostasis and inflammation.
引用
收藏
页码：450 / 455
页数：6
相关论文
共 54 条
[41]   The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R [J].
Resnati, M ;
Pallavicini, I ;
Wang, JM ;
Oppenheim, J ;
Serhan, CN ;
Romano, M ;
Blasi, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1359-1364
[42]   Plasminogen activator inhibitor type-1 deficiency does not influence the outcome of murine pneumococcal pneumonia [J].
Rijneveld, AW ;
Florquin, S ;
Bresser, P ;
Levi, M ;
de Waard, V ;
Lijnen, HR ;
Van der Zee, JS ;
Speelman, P ;
Carmeliet, P ;
van der Poll, T .
BLOOD, 2003, 102 (03) :934-939
[43]   Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia [J].
Rijneveld, AW ;
Levi, M ;
Florquin, S ;
Speelman, P ;
Carmeliet, P ;
van der Poll, T .
JOURNAL OF IMMUNOLOGY, 2002, 168 (07) :3507-3511
[44]   Impaired wound healing in mice with a disrupted plasminogen gene [J].
Romer, J ;
Bugge, TH ;
Pyke, C ;
Lund, LR ;
Flick, MJ ;
Degen, JL ;
Dano, K .
NATURE MEDICINE, 1996, 2 (03) :287-292
[45]  
Sidenius N, 2000, BLOOD, V96, P4091
[46]   Urokinase regulates vitronectin binding by controlling urokinase receptor oligomerization [J].
Sidenius, N ;
Andolfo, A ;
Fesce, R ;
Blasi, F .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (31) :27982-27990
[47]   Plasma urokinase receptor levels in patients with colorectal cancer:: Relationship to prognosis [J].
Stephens, RW ;
Nielsen, HJ ;
Christensen, IJ ;
Thorlacius-Ussing, O ;
Sorensen, S ;
Dano, K ;
Brünner, N .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (10) :869-874
[48]  
Stonehouse TJ, 1999, IMMUNOLOGY, V96, P35
[49]   Extracellular matrix moieties, cytokines, and enzymes: dynamic effects on immune cell behavior and inflammation [J].
Vaday, GG ;
Lider, O .
JOURNAL OF LEUKOCYTE BIOLOGY, 2000, 67 (02) :149-159
[50]   Urokinase receptors promote β1 integrin function through interactions with integrin α3β1 [J].
Wei, Y ;
Eble, JA ;
Wang, ZM ;
Kreidberg, JA ;
Chapman, HA .
MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (10) :2975-2986
123456