Electrochemically Initiated Oxidative Amination of Benzoxazoles Using Tetraalkylammonium Halides As Redox Catalysts

被引：119

作者：

Gao, Wei-Jing ^{[1
]}

Li, Wei-Cui ^{[1
]}

Zeng, Cheng-Chu ^{[1
]}

Tian, Hong-Yu ^{[2
]}

Hu, Li-Ming ^{[1
]}

Little, R. Daniel ^{[3
]}

机构：

[1] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China

[2] Beijing Business & Technol Univ, Food Coll, Beijing 100148, Peoples R China

[3] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 20期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

N BOND FORMATION; AMMONIUM (HYPO)IODITE CATALYSIS; CROSS-COUPLING REACTION; METAL-FREE SYNTHESIS; C-H; FREE ROUTE; IODINE; 2-AMINOBENZOXAZOLES; CHEMISTRY; ALDEHYDES;

D O I：

10.1021/jo501736w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An electrochemically promoted coupling of benzoxazoles and amines has been developed, leading directly to the formation of 2-aminobenzoxazoles. The chemistry utilizes catalytic quantities of a tetraalkylammonium halide redox catalyst and is carried out under constant current conditions in a simple undivided cell. The use of excess chemical oxidant or large amounts of supporting electrolyte is avoided. This greatly simplifies the workup and isolation process and leads to a reduction in waste.

引用

页码：9613 / 9618

页数：6

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