In situ self-assembly of peptides in glucan particles for macrophage-targeted oral delivery

被引：20

作者：

Zhang, Xu ^{[1
]}

Zhao, Yuanyuan ^{[1
]}

Xu, Yi ^{[2
]}

Pan, Yuanming ^{[1
]}

Chen, Fei ^{[1
]}

Kumar, Anil ^{[1
]}

Zou, Guozhang ^{[1
]}

Liang, Xing-Jie ^{[1
]}

机构：

[1] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

[2] China Anim Dis Control Ctr, Beijing 100125, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2014年 / 2卷 / 35期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

THIOFLAVIN-T; BETA-GLUCAN; NANOSTRUCTURES; DECTIN-1;

D O I：

10.1039/c4tb00626g

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In this study, an orally administered macrophage-targeting peptide delivery system was constructed through in situ self-assembly of Q11 peptide inside hollow glucan particles (GPs), which are approved by the FDA. The glucan shell efficiently protected the encapsulated peptide from enzymatic degradation in the gastrointestinal tract. beta-1,3-(D)-Glucan is recognized by the membrane receptor dectin-1, which is highly expressed by intestinal antigen-presenting cells, including macrophages. GPs are thus efficiently phagocytized by intestinal macrophages. This study is applicable to the pharmaceutical industry for the development of orally delivered macrophage-targeting systems for effective and personalized remedies like immunotherapeutic vaccines.

引用

页码：5882 / 5890

页数：9

共 28 条

[1] Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles
Altunbas, Aysegul
Lee, Seung J.
Rajasekaran, Sigrid A.
Schneider, Joel P.
Pochan, Darrin J.
[J]. BIOMATERIALS, 2011, 32 (25) : 5906 - 5914
[2] [Anonymous], 2010, EUROPEAN PHARMACOPOE, V7, P665
[3] Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
Aouadi, Myriam
Tesz, Gregory J.
Nicoloro, Sarah M.
Wang, Mengxi
Chouinard, My
Soto, Ernesto
Ostroff, Gary R.
Czech, Michael P.
[J]. NATURE, 2009, 458 (7242) : 1180 - U116
[4] Molecular mechanism of Thioflavin-T binding to amyloid fibrils
Biancalana, Matthew
Koide, Shohei
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2010, 1804 (07): : 1405 - 1412
[5] The effect of protein structure on their controlled release from an injectable peptide hydrogel
Branco, Monica C.
Pochan, Darrin J.
Wagner, Norman J.
Schneider, Joel P.
[J]. BIOMATERIALS, 2010, 31 (36) : 9527 - 9534
[6] Dectin-1 is a major β-glucan receptor on macrophages
Brown, GD
Taylor, PR
Reid, DM
Willment, JA
Williams, DL
Martinez-Pomares, L
Wong, SYC
Gordon, S
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (03) : 407 - 412
[7] Fungal β-glucans and mammalian immunity
Brown, GD
Gordon, S
[J]. IMMUNITY, 2003, 19 (03) : 311 - 315
[8] Enzymatic Self-Assembly of Nanostructures for Theranostics
Chen, Yue
Liang, Gaolin
[J]. THERANOSTICS, 2012, 2 (02): : 139 - 147
[9] Enzymatic modification of self-assembled peptide structures with tissue transglutaminase
Collier, JH
Messersmith, PB
[J]. BIOCONJUGATE CHEMISTRY, 2003, 14 (04) : 748 - 755
[10] Immune Therapy Steps Up the Attack
Couzin-Frankel, Jennifer
[J]. SCIENCE, 2010, 330 (6003) : 440 - 443

← 1 2 3 →